Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337486
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFrança, Carla Giometti-
dc.contributor.authorunicampSacomani, Daniel Pereira-
dc.contributor.authorunicampVillalva, Denise Gradella-
dc.contributor.authorunicampNascimento, Vicente Franco-
dc.contributor.authorunicampDávila Sánchez, José Luis-
dc.contributor.authorunicampSantana, Maria Helena Andrade-
dc.typeArtigopt_BR
dc.titleStructural changes and crosslinking modulated functional properties of oxi-HA/ADH hydrogels useful for regenerative purposespt_BR
dc.contributor.authorFrança, Carla Giometti-
dc.contributor.authorSacomani, Daniel Pereira-
dc.contributor.authorVillalva, Denise Gradella-
dc.contributor.authorNascimento, Vicente Franco-
dc.contributor.authorDávila, José Luis-
dc.contributor.authorSantana, Maria Helena Andrade-
dc.subjectÁcido hialurônicopt_BR
dc.subject.otherlanguageHyaluronic acidpt_BR
dc.description.abstractPartially oxidized hyaluronic acid (oxi-HA) crosslinked with adipic acid dihydrazide (ADH) has been explored as a promising injectable biomaterial for cell-based therapy and regenerative purposes. However, there is a lack of basic scientific studies and medical applications to support the technological approaches and optimizations of these biomaterials. Thus, we provided a relationship connecting the structural changes to the functional properties, which are modulated by the oxi-HA oxidation degree and ADH crosslinking. Oxi-HA was obtained from the reaction with sodium periodate (NaIO4), which oxidizes the proximal hydroxyl in aldehydes groups by opening the sugar ring and promoting macromolecular compaction. The results showed that the oxi-HA oxidation degree caused the structural changes that increased the zeta potential and decreased the hydrodynamic volume and viscosity. Therefore, the extrusion force, injectability, and ADH crosslinking were benefited by the click chemistry. Additionally, the ADH concentration modulated the functional properties such as the swelling, stability, gelation time and thermosensitivity of the oxi-HA/ADH hydrogels. These results are relevant for supporting the design and optimization of novel hyaluronic acid-based formulations for applications in the broad field of tissue regenerationpt_BR
dc.relation.ispartofEuropean polymer journalpt_BR
dc.relation.ispartofabbreviationEur. polym. j.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-12-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume121pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0014-3057pt_BR
dc.identifier.eissn1873-1945pt_BR
dc.identifier.doi10.1016/j.eurpolymj.2019.109288pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0014305719309590pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber140924/2017-5; 153611/2016-2pt_BR
dc.description.sponsordocumentnumber2016/10132-0pt_BR
dc.date.available2020-03-26T18:03:59Z-
dc.date.accessioned2020-03-26T18:03:59Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-03-26T18:03:59Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:20:20Z : No. of bitstreams: 1 000504504800020.pdf: 2563613 bytes, checksum: 09810365c53658318b3d145b6837d05c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-26T18:03:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337486-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Mecânicapt_BR
dc.subject.keywordAdipic acid dihydrazidept_BR
dc.subject.keywordStructure changespt_BR
dc.subject.keywordFunctional propertiespt_BR
dc.subject.keywordInjectable applicationspt_BR
dc.identifier.source000504504800020pt_BR
dc.creator.orcid0000-0003-3527-7563pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-9942-5062pt_BR
dc.creator.orcid0000-0003-0502-5963pt_BR
dc.creator.orcid0000-0002-2258-4911pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid109288pt_BR
Appears in Collections:FEQ - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000504504800020.pdf2.5 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.