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Type: Artigo
Title: Development and characterization of membranes derived from SF/GLY/58S hybrid xerogels for the release of inorganic ions as an osteogenic stimulus for bone regeneration
Author: Lopes, J.H.
França, C.G.
Beppu, M.M.
Abstract: The ternary membrane-forming system based on the silk fibroin (SF), glycerol (GLY) and sol-gel precursor of 58S bioactive glass (BG) was studied for the preparation of novel and multifunctional hybrid membranes. The morphology of membranes was observed by scanning electron microscopy (SEM) and spectral imaging, by X-ray mapping technique, were performed in order to investigate the chemical homogeneity of elements. The results show that there is a critical limit for the concentration of GLY and BG for formation of flexible membranes and without a phase separation. XRD and FTIR data showed that the GLY and BG in the silk matrix modifies the short- and intermediate-range order resulting in changes in the silk conformation, i.e., SF molecules are gradually transformed from random coils toward more stable structures – Silk I and Silk II (β-sheets). The solubility study showed that the hybrid membranes have an excellent chemical stability, confirming that the incorporation of inorganic species in the matrix allowed the preparation of novel well-controlled water-soluble membranes. The release profiles of Ca, P and Si confirmed ability of hybrid membranes to deliver controlled inorganic species, which in critical concentration, control the gene expression of osteoblasts and influences cell metabolism and function
Subject: Nanocompósitos (Materiais)
Biovidro 58S
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.eurpolymj.2019.04.030
Date Issue: Jul-2019
Appears in Collections:FEQ - Artigos e Outros Documentos

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