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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCosta, José Luiz da-
dc.typeArtigopt_BR
dc.titleDetermination of ring-substituted amphetamines through automated online hollow fiber liquid-phase microextraction-liquid chromatographypt_BR
dc.contributor.authorRodriguez Cabal, Luis Felipe-
dc.contributor.authorVargas Medina, Deyber Arley-
dc.contributor.authorCosta, Jose Luiz-
dc.contributor.authorLancas, Fernando Mauro-
dc.contributor.authorSantos-Neto, Alvaro Jose-
dc.subjectCromatografia líquidapt_BR
dc.subject.otherlanguageLiquid chromatographypt_BR
dc.description.abstractThe present paper describes an original method for the online preconcentration and analysis of ring-substituted amphetamines in urine samples, used on the integration of robot-assisted hollow fiber liquid-phase microextraction (HF-LPME), high-performance liquid chromatography (HPLC), and fluorescence detection (FLD). A lab-made autosampler, actuating a 100-mu L syringe and equipped with a three-way solenoid microvalve, allowed the acceptor phase to flow through and be withdrawn from the lumen fiber, enabling the automated online transference of the enriched acceptor phase for chromatographic analysis, through a six-port switching valve. The developed online HF-LPME-LC/FLD method demonstrated high analytical throughput and confidence, facilitating the efficient extraction and determination of the target analytes, with minimal solvent consumption and sample manipulation, in a straightforward way. Sample cleanup, analyte uptake, and analysis were carried out in 14.5 min. Under optimal conditions, automated online HF-LPME showed excellent linearity, precision, and trueness, obtaining intraday RSDs between 2.9 and 9.2% (n = 6) and interday RSDs between 5.3 and 9.3% (n = 6). Enrichment factors (EFs) ranged between 14.2 and 15.7, extraction recoveries (ERs) ranged between 17.7 and 19.5%, and the limits of detection (S/N = 3) were 2.0, 3.0, and 3.0 mu g L-1 for MDA, MDMA, and MDEA, respectively. The method proved to be an effortless, rapid, reliable, and environment-friendly approach for the determination of drug abuse in urine samplespt_BR
dc.relation.ispartofAnalytical and bioanalytical chemistrypt_BR
dc.relation.ispartofabbreviationAnal. bioanal. chem.pt_BR
dc.publisher.cityHeidelbergpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherSpringerpt_BR
dc.date.issued2019-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume411pt_BR
dc.description.issuenumber29pt_BR
dc.description.firstpage7889pt_BR
dc.description.lastpage7897pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1618-2642pt_BR
dc.identifier.eissn1618-2650pt_BR
dc.identifier.doi10.1007/s00216-019-02196-0pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00216-019-02196-0pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber59326/2014-7; 307293/2014-9; 311300/2015-4; 425814/2018-1pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2010/19910-9; 2014/03795-0; 2016/21950-5; 2017/02147-0pt_BR
dc.date.available2020-03-26T16:00:02Z-
dc.date.accessioned2020-03-26T16:00:02Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-03-26T16:00:02Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:20:14Z : No. of bitstreams: 1 000502969200027.pdf: 1416544 bytes, checksum: 7fb9a47c0c28bd1e61bd644632353c7c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-26T16:00:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337466-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.subject.keywordAutomationpt_BR
dc.subject.keywordMicroextractionpt_BR
dc.subject.keywordSample preparationpt_BR
dc.subject.keywordMass spectrometrypt_BR
dc.identifier.source000502969200027pt_BR
dc.creator.orcid0000-0001-9607-3391pt_BR
dc.type.formArtigo de pesquisapt_BR
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