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Type: Artigo
Title: Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice
Author: Branco Ramos Nakandakari, Susana Castelo
Munoz, Vitor Rosetto
Kuga, Gabriel Keine
Gaspar, Rafael Calais
Sant'Ana, Marcella Ramos
Betim Pavan, Isadora Carolina
Salvino da Silva, Luiz Guilherme
Morelli, Ana Paula
Simabuco, Fernando Moreira
Ramos da Silva, Adelino Sanchez
de Moura, Leandro Pereira
Ropelle, Eduardo Rochete
Cintra, Dennys Esper
Pauli, Jose Rodrigo
Abstract: The consumption of saturated fatty acids is one of the leading risk factors for Alzheimer's Disease (AD) development. Indeed, the short-term consumption of a high-fat diet (HFD) is related to increased inflammatory signals in the hippocampus; however, the potential molecular mechanisms linking it to AD pathogenesis are not fully elucidated. In our study, we investigated the effects of short-term HFD feeding (within 3, 7 and 10 days) in AD markers and neuroinflammation in the hippocampus of mice. The short period of HFD increased fasting glucose and HOMA-IR. Also, mice fed HFD increased the protein content of beta-Amyloid, pTau, TNF alpha, IL1 beta, pJNK, PTP1B, peIF2 alpha, CHOP, Caspase3, Cleaved-Caspase3 and Alzheimer-related genes (Bax, PS1, PEN2, Aph1b). At 10 days, both neuronal (N2a) and microglial (BV2) cells presented higher expression of inflammatory and apoptotic genes when stimulated with palmitate. These findings suggest that a short period of consumption of a diet rich in saturated fat is associated with activation of inflammatory, ER stress and apoptotic signals in the hippocampus of young mice
Subject: Ácidos graxos saturados
Doença de Alzheimer
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.bbi.2019.02.016
Date Issue: 2019
Appears in Collections:FCA - Artigos e Outros Documentos

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