Please use this identifier to cite or link to this item:
Type: Artigo
Title: CD1 is involved in diet-induced hypothalamic inflammation in obesity
Author: Bombassaro, Bruna
Ramalho, Albina F. S.
Fioravante, Milena
Solon, Carina
Nogueira, Guilherme
Nogueira, Pedro A. S.
Gaspar, Rodrigo S.
Ropelle, Eduardo R.
Velloso, Licio A.
Abstract: Obesity-associated hypothalamic inflammation plays an important role in the development of defective neuronal control of whole body energy balance. Because dietary fats are the main triggers of hypothalamic inflammation, we hypothesized that CD1, a lipid-presenting protein, may be involved in the hypothalamic inflammatory response in obesity. Here, we show that early after the introduction of a high-fat diet, CD1 expressing cells gradually appear in the mediobasal hypothalamus. The inhibition of hypothalamic CD1 reduces diet-induced hypothalamic inflammation and rescues the obese and glucose-intolerance phenotype of mice fed a high-fat diet. Conversely, the chemical activation of hypothalamic CD1 further increases diet-induced obesity and hypothalamic inflammation. A bioinformatics analysis revealed that hypothalamic CD1 correlates with transcripts encoding for proteins known to be involved in diet-induced hypothalamic abnormalities in obesity. Thus, CD1 is involved in at least part of the hypothalamic inflammatory response in diet-induced obesity and its modulation affects the body mass phenotype of mice
Subject: Linfócitos
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.bbi.2019.01.011
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000468256900011.pdf3.84 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.