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Type: Artigo
Title: Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women : a preliminary study
Author: Cardinelli, Camila de Siqueira
Torrinhas, Raquel Susana
Sala, Priscila
Pudenzi, Marcos Albieri
Angolini, Celio Fernando F.
da Silva, Mariane Marques
Machado, Natasha Mendonca
Ravacci, Graziela
Eberlin, Marcos N.
Waitzberg, Dan L.
Abstract: To assess the influence of Roux-en-Y gastric by-pass (RYGB) on fecal bile acid (BA) profile and its relationship with postoperative remission of type 2 diabetes (T2D). Fecal samples were collected 3 and 12 months after RYGB from diabetic obese women who were responsive (n = 12) and non-responsive (n = 8) to postoperative remission of T2D. Fecal BA profile was accessed by liquid chromatography coupled to tandem mass spectrometry in a targeted approach. Relative to pre-operative levels, a total of 10 fecal BA profiles decreased after RYGB (ANOVA, p <= 0.05) with significant fold-changes for glycochenodeoxycholic, glycocholic, taurocholic, and taurochenodeoxycholic acids at 3-months postoperatively, and for glycochenodeoxycholic, glycocholic and taurocholic acids at 12 months postoperatively (Benjamini-Hochberg, p < 0.05). Postoperative changes in fecal BA were different between responsive and non-responsive women, with a significant reduction in more sub-fractions of BA in responsive women than in non-responsive women, and a marked difference in the temporal behavior of cholic acid (CA) and chenodeoxycholic acid (CDCA), thus reflecting changes in CA/CDCA ratio, and tauroursodeoxycolic (TUDCA) levels between these responsiveness groups (ANOVA, p <= 0.05). RYGB induces a marked reduction in the concentration of fecal BA, which is heterogeneous according to T2D responsiveness
Subject: Cirurgia bariátrica
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.clnu.2018.12.028
Date Issue: 2019
Appears in Collections:IQ - Artigos e Outros Documentos

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