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Type: Artigo
Title: Butyrate protects mice from Clostridium difficile-induced colitis through an HIF-1-dependent mechanism
Author: Fachi, Jose Luis
Felipe, Jaqueline de Souza
Pral, Lais Passariello
da Silva, Bruna Karadi
Correa, Renan Oliveira
Pereira de Andrade, Mirella Cristiny
da Fonseca, Denise Morais
Basso, Paulo Jose
Saraiva Camara, Niels Olsen
de Sales e Souza, Ericka Lorenna
Martins, Flaviano dos Santos
Sato Guima, Suzana Eiko
Thomas, Andrew Maltez
Setubal, Joao Carlos
Magalhaes, Yuli Thamires
Forti, Fabio Luis
Candreva, Thamiris
Rodrigues, Hosana Gomes
de Jesus, Marcelo Bispo
Consonni, Silvio Roberto
Farias, Alessandro dos Santos
Varga-Weisz, Patrick
Ramirez Vinolo, Marco Aurelio
Abstract: Antibiotic-induced dysbiosis is a key factor predisposing intestinal infection by Clostridium difficile. Here, we show that interventions that restore butyrate intestinal levels mitigate clinical and pathological features of C. difficile-induced colitis. Butyrate has no effect on C. difficile colonization or toxin production. However, it attenuates intestinal inflammation and improves intestinal barrier function in infected mice, as shown by reduced intestinal epithelial permeability and bacterial translocation, effects associated with the increased expression of components of intestinal epithelial cell tight junctions. Activation of the transcription factor HIF-1 in intestinal epithelial cells exerts a protective effect in C. difficile-induced colitis, and it is required for butyrate effects. We conclude that butyrate protects intestinal epithelial cells from damage caused by C. difficile toxins via the stabilization of HIF-1, mitigating local inflammatory response and systemic consequences of the infection
Subject: Butiratos
Country: Estados Unidos
Editor: Elsevier
Rights: Aberto
Identifier DOI: 10.1016/j.celrep.2019.03.054
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos

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