Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337295
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMichelon, Mariano-
dc.contributor.authorunicampTorre, Lucimara Gaziola de la-
dc.contributor.authorunicampCunha, Rosiane Lopes da-
dc.typeOutro documentopt_BR
dc.titleSingle-step microfluidic production of W/O/W double emulsions as templates for beta-carotene-loaded giant liposomes formationpt_BR
dc.contributor.authorMichelon, Mariano-
dc.contributor.authorHuang, Yuting-
dc.contributor.authorde la Torre, Lucimara Gaziola-
dc.contributor.authorWeitz, David A.-
dc.contributor.authorCunha, Rosiane Lopes-
dc.subjectMicrofluidicapt_BR
dc.subject.otherlanguageMicrofluidicspt_BR
dc.description.abstractWe demonstrated the microfluidic production of W/O/W double emulsion droplets aiming formation of beta-carotene-incorporated giant liposomes for food and/or pharmaceutical applications. For this purpose, glass-capillary microfluidic devices were fabricated to create a truly three-dimensional flow aiming production of giant unilamellar liposomes by solvent evaporation process after W/O/W double emulsion droplet templates formation. A great challenge of microfluidic production of monodisperse and stable W/O/W double emulsion templates for this proposal is the replacement of organic solvents potentially toxic for phospholipids dissolution. Besides, the high cost of several semi-synthetic phospholipids commonly used for giant liposome formation remains as a major technological challenge to be overcome. Thus, beta-carotene-incorporated giant liposomes were generated using biocompatible solvents with low toxic potential (ethyl acetate and pentane) and non-purified soybean lecithin - a food-grade phospholipid mixture with low cost - by dewetting and evaporation of the solvents forming the oily intermediate phase of W/O/W double emulsion droplet templates. Our results showed monodisperse beta-carotene-loaded giant liposomes with diameter ranging between 100 mu m and 180 mu m and a stability of approximately 7 days. In this way, a single-step microfluidic process with highly accurate control of size distribution was developed. This microfluidic process proposed is potentially useful for a broad range of applications in protection and delivery of active compoundspt_BR
dc.relation.ispartofChemical engineering journalpt_BR
dc.relation.ispartofabbreviationChem. eng. j.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume366pt_BR
dc.description.firstpage27pt_BR
dc.description.lastpage32pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1385-8947pt_BR
dc.identifier.eissn1873-3212pt_BR
dc.identifier.doi10.1016/j.cej.2019.02.021pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1385894719302384pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber140283/2013-7; 305477/2012-9pt_BR
dc.date.available2020-03-24T19:19:22Z-
dc.date.accessioned2020-03-24T19:19:22Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-03-24T19:19:22Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-24T19:19:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337295-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.departmentDepartamento de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.subject.keywordGlass-capillarypt_BR
dc.subject.keywordSoybean lecithinpt_BR
dc.subject.keywordSolventspt_BR
dc.identifier.source000459903100004pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-8179-1160pt_BR
dc.creator.orcid0000-0003-2228-5492pt_BR
dc.type.formComunicação curtapt_BR
dc.description.sponsorNoteThe authors would like to thank CNPq (140283/2013-7 and 305477/2012-9) and FAEPEX/UNICAMP (2146-16)pt_BR
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