Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337273
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCarvalho, Eduardo George Batista de-
dc.contributor.authorunicampMachado Júnior, Almiro José-
dc.contributor.authorunicampPauna, Henrique Furlan-
dc.contributor.authorunicampNicola, Ester Maria Danielli-
dc.contributor.authorunicampAltemani, Albina Messias de Almeida Milani-
dc.contributor.authorunicampCrespo, Agrício Nubiato-
dc.typeArtigopt_BR
dc.titleThe effect of fibroblast growth factors in grafted fascia into the vocal fold of rabbitspt_BR
dc.contributor.authorCarvalho, Eduardo G. B.-
dc.contributor.authorMachado-Junior, Almiro J.-
dc.contributor.authorPauna, Henrique F.-
dc.contributor.authorNicola, Ester M. D.-
dc.contributor.authorAltemani, Albina M. A. M.-
dc.contributor.authorCrespo, Agricio N.-
dc.subjectFibroblastospt_BR
dc.subjectCordas vocaispt_BR
dc.subjectCoelhopt_BR
dc.subject.otherlanguageFibroblastspt_BR
dc.subject.otherlanguageVocal cordspt_BR
dc.subject.otherlanguageRabbitspt_BR
dc.description.abstractThe human larynx is a very important organ for communication. Many conditions lead to scarring of the vocal folds, decreasing voice quality. Objective We aimed to determine whether fibroblast growth factors (FGFs) may influence tissue integration of grafted fascia into the vocal folds of an animal model. This is an experimental animal study with 12 adult rabbits that were submitted to a grafting fragment obtained from superficial cervical fascia into the vocal fold lamina propria, bilaterally. The right vocal fold was injected with FGFs. The animals were sacrificed after 1 month or 12 months, depending on the group they were assigned to, and a histological analysis of their vocal folds was performed. We analyzed the histological changes (such as the presence of fibrosis and neovascularization) induced by the acute or chronic inflammatory reactions. Results The FGFs induced acute inflammatory changes in all animals after 1 month of the initial experiment. The presence of FGFs triggered more fibrosis than the expected due to the surgical procedure itself when compared with the control side of all animals after 12 months of the initial experiment. Conclusions Fibroblast growth factors alone do not represent a good therapeutic option in phonosurgery, since we observed higher levels of fibrosis in the vocal fold lamina propria. Further studies combining more substances may be necessary to elucidate the best option to be used in this kind of surgery.pt_BR
dc.relation.ispartofInternational achives of otorhinolaryngologypt_BR
dc.publisher.cityStuttgartpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherGeorg Thieme Verlagpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume23pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage60pt_BR
dc.description.lastpage64pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1809-9777pt_BR
dc.identifier.eissn1809-4864pt_BR
dc.identifier.doi10.1055/s-0038-1661399pt_BR
dc.identifier.urlhttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1661399pt_BR
dc.date.available2020-03-24T16:49:00Z-
dc.date.accessioned2020-03-24T16:49:00Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-03-24T16:49:00Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-24T16:49:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337273-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Oftalmologia e Otorrinolaringologiapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Oftalmologia e Otorrinolaringologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordFGFspt_BR
dc.subject.keywordGraftingpt_BR
dc.subject.keywordFasciapt_BR
dc.identifier.source000455643900010pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0002-1274-8695pt_BR
dc.creator.orcidorcid.org/0000-0002-5575-7030pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0003-3133-4356pt_BR
dc.type.formArtigo originalpt_BR
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