Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337258
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCosta, Jonas Henrique-
dc.contributor.authorunicampBazioli, Jaqueline Moraes-
dc.contributor.authorunicampAraújo, Éder de Vilhena-
dc.contributor.authorunicampVendramini, Pedro Henrique-
dc.contributor.authorunicampEberlin, Marcos Nogueira-
dc.contributor.authorunicampFill, Taicia Pacheco-
dc.typeArtigopt_BR
dc.titleMonitoring indole alkaloid production by penicillium digitatum during infection process in citrus by mass spectrometry Imaging and molecular networkingpt_BR
dc.contributor.authorCosta, Jonas Henrique-
dc.contributor.authorBazioli, Jaqueline Moraes-
dc.contributor.authorAraujo, Eder de Vilhena-
dc.contributor.authorVendramini, Pedro Henrique-
dc.contributor.authorPorto, Mariana Cristina C. de Freitas-
dc.contributor.authorEberlin, Marcos Nogueira-
dc.contributor.authorSouza-Neto, Jayme A.-
dc.contributor.authorFill, Taicia Pacheco-
dc.subjectAlcaloidespt_BR
dc.subjectMetabólitospt_BR
dc.subject.otherlanguageAlkaloidspt_BR
dc.subject.otherlanguageMetabolitespt_BR
dc.description.abstractGreen mold, caused by Penicillium digitatum, is the most destructive post-harvest disease in citrus. Secondary metabolites produced by fungal phytopathogens have been associated with toxicity to their respective host through the interaction with a wide range of cell targets. Natural products have also been described as important molecules for biocontrol and competition in their respective environment. For P. digitatum, the production of indole alkaloids, tryptoquialanines A and B, have been reported. However, their biological role remains unknown. Mass Spectrometry Imaging (MSI) technique was applied here for the first time to monitor the secondary metabolites produced on the orange surface during infection in order to gain insights about the P. digitatum-citrus interaction mechanisms. Through the combination of MSI and molecular networking it was possible to report, for the first time, the production of trypto-quivalines and fumiquinazolines by P. digitatum and also the accumulation of tryptoquialanines on the fruit surface from 4 to 7 d post inoculation. P. digitatum was also evaluated concerning the ability to sinthesize indole alkaloids in vivo in the different citrus hosts. The biological role of tryptoquialanines was investigated and tryptoquialanine A was submitted to insecticidal bioassays that revealed its high toxicity against Aedes Aegypti, suggesting an important insecticidal action during orange decaypt_BR
dc.relation.ispartofFungal biologypt_BR
dc.relation.ispartofabbreviationFungal biolpt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume123pt_BR
dc.description.issuenumber8pt_BR
dc.description.lastpage594pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1878-6146pt_BR
dc.identifier.eissn1878-6162pt_BR
dc.identifier.doi10.1016/j.funbio.2019.03.002pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1878614619300352pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber8887.137194/2017-00pt_BR
dc.description.sponsordocumentnumber2017/24462-4; 2018/03670-0; 2013/11343-6pt_BR
dc.date.available2020-03-24T15:22:03Z-
dc.date.accessioned2020-03-24T15:22:03Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-03-24T15:22:03Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:18:48Z : No. of bitstreams: 1 000480379000005.pdf: 1496234 bytes, checksum: 996ca9f7905cb0e28677f54052b1b04f (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-24T15:22:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337258-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.subject.keywordCitrus green moldpt_BR
dc.subject.keywordInsecticidal activitypt_BR
dc.identifier.source000480379000005pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4101-5471pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0003-4868-0618pt_BR
dc.creator.orcid0000-0003-4724-5251pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid600pt_BR
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