Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337245
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampEs, Ismail-
dc.contributor.authorunicampMousavi Khaneghah, Amin-
dc.typeArtigopt_BR
dc.titleThe application of the CRISPR-Cas9 genome editing machinery in food and agricultural science : current status, future perspectives, and associated challengespt_BR
dc.contributor.authorEş, Ismail-
dc.contributor.authorGavahian, Mohsen-
dc.contributor.authorMarti-Quijal, Francisco J.-
dc.contributor.authorLorenzo, Jose M.-
dc.contributor.authorKhaneghah, Amin Mousavi-
dc.contributor.authorTsatsanis, Christos-
dc.contributor.authorKampranis, Sotirios C.-
dc.contributor.authorBarba, Francisco J.-
dc.subjectAgriculturapt_BR
dc.subjectCompostos bioativospt_BR
dc.subject.otherlanguageAgriculturept_BR
dc.subject.otherlanguageBioactive compoundspt_BR
dc.description.abstractThe recent progress in genetic engineering has brought multiple benefits to the food and agricultural industry by enhancing the essential characteristics of agronomic traits. Powerful tools in the field of genome editing, such as siRNA-mediated RNA interference for targeted suppression of gene expression and transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs) for DNA repair have been widely used for commercial purposes. However, in the last few years, the discovery of the CRISPR-Cas9 system has revolutionized genome editing and has attracted attention as a powerful tool for several industrial applications. Herein, we review current progresses in the utilization of the CRISPR-Cas9 system in the food and agricultural industry, particularly in the development of resistant crops with improved quality and productivity. We compare the CRISPR system with the TALEN and ZFN nucleases–based methods and highlight potential advantages and shortcomings. In addition, we explore the state of the global market and discuss the safety and ethical concerns associated with the application of this technology in the food and agricultural industrypt_BR
dc.relation.ispartofBiotechnology Advancespt_BR
dc.relation.ispartofabbreviationBiotechnol. adv.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-05-
dc.date.monthofcirculationMay.pt_BR
dc.language.isoengpt_BR
dc.description.volume37pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage410pt_BR
dc.description.lastpage421pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0734-9750pt_BR
dc.identifier.eissn1873-1899pt_BR
dc.identifier.doi10.1016/j.biotechadv.2019.02.006pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0734975019300254pt_BR
dc.date.available2020-03-24T14:09:13Z-
dc.date.accessioned2020-03-24T14:09:13Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-03-24T14:09:13Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:17:23Z : No. of bitstreams: 1 000464301900004.pdf: 963352 bytes, checksum: 0f60cb182ab3b7a36d22ae7a529797c2 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-24T14:09:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-05en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337245-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordCRISPR-Cas9pt_BR
dc.subject.keywordSingle guide RNApt_BR
dc.subject.keywordPlant genome editingpt_BR
dc.subject.keywordFood applicationspt_BR
dc.identifier.source000464301900004pt_BR
dc.creator.orcid0000-0002-7369-1039pt_BR
dc.creator.orcid0000-0001-5769-0004pt_BR
dc.type.formArtigo de Revisãopt_BR
dc.description.sponsorNoteMohsen Gavahian would like to thank the support of Ministry of Economic Affairs, project no. 107-EC-17-A-22-0332 and 108-EC-17-A-22-0332, Taiwan, Republic of China. Work in the laboratory of Sotirios C. Kampranis is supported by the Novo Nordisk Foundation (grants: NNF16OC0021760, NNF17OC0027646, NNF18OC0034784, NNF18OC0031872, NNF16OC0019554) and the Independent Research Fund Denmark (grants: DFF-7017-00275 and 8022-00254B)pt_BR
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