Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337240
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMariano, Fernanda Viviane-
dc.contributor.authorunicampCasarim, André Luís Maion-
dc.contributor.authorunicampMartins, Antônio Santos-
dc.contributor.authorunicampScarini, João Figueira-
dc.contributor.authorunicampSouza, Reydson Alcides de Lima-
dc.contributor.authorunicampEgal, Erika Said Abu-
dc.contributor.authorunicampAltemani, Albina Messias de Almeida Milani-
dc.typeArtigopt_BR
dc.titleSomatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenomapt_BR
dc.contributor.authorMariano, Fernanda Viviane-
dc.contributor.authorFidalgo, Felipe-
dc.contributor.authorMaion Casarim, Andre Luis-
dc.contributor.authorMartins, Antonio Santos-
dc.contributor.authorScarini, Joao Figueira-
dc.contributor.authorde Lima Souza, Reydson Alcides-
dc.contributor.authorEgal, Erika Said-
dc.contributor.authorKowalski, Luiz Paulo-
dc.contributor.authorVictorino Krepischi, Ana Cristina-
dc.contributor.authorAltemani, Albina-
dc.subjectGlândula parótidapt_BR
dc.subjectAdenoma pleomorfopt_BR
dc.subject.otherlanguageParotid glandpt_BR
dc.subject.otherlanguageAdenoma, pleomorphicpt_BR
dc.description.abstractObjective. As the genetic changes in recurrent pleomorphic adenoma (RPA) have not yet been investigated, the aim of this study was to assess the genomic profile of somatic copy number alteration in RPA and pleomorphic adenoma (PA) by using array comparative genomic hybridization (aCGH). Study Design. Four cases of RPA and 13 cases of PA were evaluated by using aCGH, using a 180 K platform. Data were analyzed by using Nexus Copy Number Discovery. Results. The RPA group rarely showed any copy number alteration, except for 1 case that exhibited losses in 5 p15.33 p15.1, 5 g13.1 q35.3 and 12 q12 813.11. The PA group also showed few copy number alterations, and the most frequent findings involved chromosomes 8: 8p21.3-p12 (gain), 8q12.1 (loss), 8p23.3-q24.3 (gain), and 8q12.1-q21.11 (gain). Genomic amplifications were revealed in the PA group, and the relevant affected genes were MAML2 and LIFR. Conclusions. PA and RPA exhibit few somatic copy number alterations and show a similar genomic profile on aCGH.pt_BR
dc.relation.ispartofOral surgery, oral medicine, oral pathology and oral radiologypt_BR
dc.relation.ispartofabbreviationOral surg. oral med. oral pathol. oral radiol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevierpt_BR
dc.date.issued2020-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume129pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage59pt_BR
dc.description.lastpage64pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2212-4403pt_BR
dc.identifier.eissn2212-4411pt_BR
dc.identifier.doi10.1016/j.oooo.2019.08.016pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2212440319314221pt_BR
dc.description.sponsorshipFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulopt_BR
dc.description.sponsordocumentnumber11/23204-5; 11/23366-5; 15/07304-0; 17/00831-0pt_BR
dc.date.available2020-03-24T13:48:17Z-
dc.date.accessioned2020-03-24T13:48:17Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-03-24T13:48:17Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-24T13:48:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337240-
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000505161100012pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0001-9015-6831pt_BR
dc.creator.orcidorcid.org/0000-0001-5045-6960pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo de pesquisapt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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