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Type: Artigo
Title: Somatic copy number alterations in pleomorphic adenoma and recurrent pleomorphic adenoma
Author: Mariano, Fernanda Viviane
Fidalgo, Felipe
Maion Casarim, Andre Luis
Martins, Antonio Santos
Scarini, Joao Figueira
de Lima Souza, Reydson Alcides
Egal, Erika Said
Kowalski, Luiz Paulo
Victorino Krepischi, Ana Cristina
Altemani, Albina
Abstract: Objective. As the genetic changes in recurrent pleomorphic adenoma (RPA) have not yet been investigated, the aim of this study was to assess the genomic profile of somatic copy number alteration in RPA and pleomorphic adenoma (PA) by using array comparative genomic hybridization (aCGH). Study Design. Four cases of RPA and 13 cases of PA were evaluated by using aCGH, using a 180 K platform. Data were analyzed by using Nexus Copy Number Discovery. Results. The RPA group rarely showed any copy number alteration, except for 1 case that exhibited losses in 5 p15.33 p15.1, 5 g13.1 q35.3 and 12 q12 813.11. The PA group also showed few copy number alterations, and the most frequent findings involved chromosomes 8: 8p21.3-p12 (gain), 8q12.1 (loss), 8p23.3-q24.3 (gain), and 8q12.1-q21.11 (gain). Genomic amplifications were revealed in the PA group, and the relevant affected genes were MAML2 and LIFR. Conclusions. PA and RPA exhibit few somatic copy number alterations and show a similar genomic profile on aCGH.
Subject: Glândula parótida
Adenoma pleomorfo
Country: Holanda
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.oooo.2019.08.016
Date Issue: 2020
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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