Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337232
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampTortorelli, Gabriela Arielo-
dc.contributor.authorunicampTorricelli, Caroline-
dc.contributor.authorunicampCarron, Juliana-
dc.contributor.authorunicampCosta, Ericka Francislaine Dias-
dc.contributor.authorunicampLopes-Aguiar, Leisa-
dc.contributor.authorunicampCarvalho, Bruna Fernandes-
dc.contributor.authorunicampRinck Júnior, José Augusto-
dc.contributor.authorunicampMariano, Fernanda Viviane-
dc.contributor.authorunicampAltemani, Albina Messias de Almeida Milani-
dc.contributor.authorunicampLima, Carmen Silvia Passos-
dc.contributor.authorunicampLourenço, Gustavo Jacob-
dc.typeOutro documentopt_BR
dc.titleCASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian populationpt_BR
dc.contributor.authorTortorelli, Gabriela Arielo-
dc.contributor.authorTorricelli, Caroline-
dc.contributor.authorCarron, Juliana-
dc.contributor.authorDias Costa, Ericka Francislaine-
dc.contributor.authorLopes-Aguiar, Leisa-
dc.contributor.authorCarvalho, Bruna Fernandes-
dc.contributor.authorRinck-Junior, Jose Augusto-
dc.contributor.authorMariano, Fernanda Viviane-
dc.contributor.authorAlmeida Milani Altemani, Albina Messias-
dc.contributor.authorPassos Lima, Carmen Silvia-
dc.contributor.authorLourenco, Gustavo Jacob-
dc.subjectNeoplasias orofaríngeaspt_BR
dc.subjectApoptosept_BR
dc.subject.otherlanguageOropharyngeal Neoplasmspt_BR
dc.subject.otherlanguageApoptosispt_BR
dc.description.abstractThe objective of this research was to assess the association of genetic polymorphisms related to intrinsic apoptosis pathway CASP8 rs3834129 and CASP3 rs4647601 with the risk, clinical and pathological aspects, and survival of oropharynx squamous cell carcinoma (OPSCC) patients that received cisplatin and radiotherapy. The genotypes were identified in 198 patients with OPSCC and 200 controls using polymerase chain reaction methods. Chi square or Fisher's exact test and logistic regression were applied for the detection of differences between groups. Patients' genotypes were statistically evaluated considering the event-free survival and overall analysis using Kaplan-Meier estimate and Cox regression. CASP3 rs4647601 GG genotype (44.4% vs. 30.0%, p = 0.03) and G allele (63.9% vs. 55.5%, p = 0.04) were more common in patients with OPSCC than in controls. Carriers of GG genotype and G allele were under 1.78-fold and 1.40-fold increased risk of OPSCC than others, respectively. The frequency of CASP8 rs3834129 DD genotype was higher in patients with OPSCC with poorly differentiated or undifferentiated tumors when compared to others (34.5% vs. 16.1%, p = 0.02). No influence of CASP8 and CASP3 polymorphisms on OPSCC patients' survival was seen in this study. Our results indicate that inherited genetic variants in the intrinsic apoptosis pathway related to CASP3 rs4647601 and CASP8 rs3834129 polymorphisms may be an important determinant of OPSCC risk and tumor cell differentiation.pt_BR
dc.relation.ispartofMolecular biology reports: an international journal on molecular and cellular biologypt_BR
dc.relation.ispartofabbreviationMol. biol. rep.pt_BR
dc.publisher.cityDordrechtpt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2019-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume46pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage6557pt_BR
dc.description.lastpage6563pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0301-4851pt_BR
dc.identifier.eissn1573-4978pt_BR
dc.identifier.doi10.1007/s11033-019-05107-9pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11033-019-05107-9pt_BR
dc.description.sponsorshipCNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-03-24T13:07:19Z-
dc.date.accessioned2020-03-24T13:07:19Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-03-24T13:07:19Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-24T13:07:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337232-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentLaboratório de Genética do Câncerpt_BR
dc.contributor.unidadeFaculdade de Ciências Farmacêuticaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordCASP8pt_BR
dc.subject.keywordCASP3pt_BR
dc.subject.keywordPolymorphismpt_BR
dc.subject.keywordRiskpt_BR
dc.subject.keywordTumor cell differentiationpt_BR
dc.subject.keywordPrognosispt_BR
dc.identifier.source000489845900002pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0002-1544-8591pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0002-1314-2345pt_BR
dc.creator.orcidorcid.org/0000-0002-5944-0305pt_BR
dc.type.formComunicaçãopt_BR
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