Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337211
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCaloto-Oliveira, Ádria-
dc.contributor.authorunicampSilva, João Gabriel Mesquita-
dc.contributor.authorunicampAzevedo, Carina Cristina de Jesus-
dc.typeArtigopt_BR
dc.titleSingle and mixture toxicity of four pharmaceuticals of environmental concern to aquatic organisms, including a behavioral assessmentpt_BR
dc.contributor.authorGodoy, Aline Andrade-
dc.contributor.authorOliveira, Adria Caloto de-
dc.contributor.authorSilva, Joao Gabriel Mesquita-
dc.contributor.authorAzevedo, Carina Cristina de Jesus-
dc.contributor.authorDomingues, Ines-
dc.contributor.authorNogueira, Antonio Jose Arsenia-
dc.contributor.authorKummrow, Fabio-
dc.subjectToxicidadept_BR
dc.subjectAgentes hipoglicemicospt_BR
dc.subject.otherlanguageToxicitypt_BR
dc.subject.otherlanguageHypoglycemic agentspt_BR
dc.description.abstractPharmaceuticals are frequently detected in aquatic environments as mixtures and can cause toxic effects to non-target organisms. We aimed to evaluate the single and mixture effects of the pharmaceuticals metformin, bisoprolol, ranitidine and sotalol using Daphnia similis and Danio rerio. In addition, we aimed to test the predictive accuracy of the mathematical models concentration addition and independent action and to evaluate the nature of the possible toxicological interactions among these pharmaceuticals using the combination index-isobologram model. The acute toxicity of these four pharmaceuticals individually and of their binary mixtures were evaluated using the D. similis tests. Developmental and behavioral effects induced by the pharmaceuticals in quaternary mixtures were evaluated using D. rerio embryos. We observed that most of the binary mixture effects were in the zone between the effects predicted by the concentration addition and the independent action model. The combination index-isobologram model showed to be adequate to describe the nature of possible interactions occurring between the combined pharmaceuticals. Developmental and behavioral acute adverse effects seem not to be induced by the joint action of the quaternary mixture of the evaluated pharmaceuticals on D. rerio embryos, at the concentrations at which they are usually found in surface fresh waters. However, from the results obtained with D. similis, we can conclude that assessing the ecological risk based on the effects of individual pharmaceuticals can underestimate the risk level posed by these environmental contaminantspt_BR
dc.relation.ispartofChemospherept_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume235pt_BR
dc.description.firstpage373pt_BR
dc.description.lastpage382pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0045-6535pt_BR
dc.identifier.eissn1879-1298pt_BR
dc.identifier.doi10.1016/j.chemosphere.2019.06.200pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0045653519314419pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível Superiorpt_BR
dc.description.sponsordocumentnumber88881.132858/2016-01pt_BR
dc.date.available2020-03-23T19:27:54Z-
dc.date.accessioned2020-03-23T19:27:54Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-03-23T19:27:54Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-23T19:27:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337211-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.contributor.unidadeFaculdade de Tecnologiapt_BR
dc.subject.keywordBetablockerspt_BR
dc.subject.keywordLocomotor activitypt_BR
dc.subject.keywordSynergismpt_BR
dc.identifier.source000487567000040pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-5216-0987pt_BR
dc.type.formArtigopt_BR
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