Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337207
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAlmeida, Oslei Paes de-
dc.contributor.authorunicampMariano, Fernanda Viviane-
dc.typeArtigopt_BR
dc.titleFatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenomapt_BR
dc.contributor.authorPulido Diaz, Katya-
dc.contributor.authorGondak, Rogerio-
dc.contributor.authorMartins, Leandro Liporoni-
dc.contributor.authorde Almeida, Oslei Paes-
dc.contributor.authorLeon, Jorge Esquiche-
dc.contributor.authorMariano, Fernanda Viviane-
dc.contributor.authorAltemani, Albina-
dc.contributor.authorVargas, Pablo Agustin-
dc.subjectGlândulas salivarespt_BR
dc.subjectAdenoma pleomorfopt_BR
dc.subject.otherlanguageSalivary glandspt_BR
dc.subject.otherlanguageAdenoma, pleomorphicpt_BR
dc.description.abstractFatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA.pt_BR
dc.relation.ispartofJournal of oral pathology and medicinept_BR
dc.relation.ispartofabbreviationJ. oral pathol. med.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2018-
dc.date.monthofcirculationDec.pt_BR
dc.language.isoengpt_BR
dc.description.volume48pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage232pt_BR
dc.description.lastpage238pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.eissn1600-0714pt_BR
dc.identifier.doi10.1111/jop.12820pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jop.12820pt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível Superiorpt_BR
dc.description.sponsorshipCNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP – Fundação de Amparo à Pesquisa Do Estado De São Paulopt_BR
dc.description.sponsordocumentnumber5881102pt_BR
dc.description.sponsordocumentnumber305967/2014-20pt_BR
dc.description.sponsordocumentnumber2012/10781-7; 2015/07304-0pt_BR
dc.date.available2020-03-23T18:57:37Z-
dc.date.accessioned2020-03-23T18:57:37Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-03-23T18:57:37Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-23T18:57:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337207-
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordFatty acid synthasept_BR
dc.subject.keywordSalivary gland tumorspt_BR
dc.subject.keywordTumor cell proliferationpt_BR
dc.identifier.source000460347600007pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo originalpt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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