Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337207
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbnFechadopt_BR
dc.contributor.authorunicampAlmeida, Oslei Paes de-
dc.contributor.authorunicampMariano, Fernanda Viviane-
dc.contributor.authorunicampAlmeida, Oslei Paes dept_BR
dc.contributor.authorunicampMariano, Fernanda Vivianept_BR
dc.contributor.authorunicampAltemani, Albina Messias de Almeida Milanipt_BR
dc.contributor.authorunicampVargas, Pablo Agustinpt_BR
dc.typeArtigopt_BR
dc.titleFatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenomapt_BR
dc.contributor.authorPulido Diaz, Katya-
dc.contributor.authorGondak, Rogerio-
dc.contributor.authorMartins, Leandro Liporoni-
dc.contributor.authorde Almeida, Oslei Paes-
dc.contributor.authorLeon, Jorge Esquiche-
dc.contributor.authorMariano, Fernanda Viviane-
dc.contributor.authorAltemani, Albina-
dc.contributor.authorVargas, Pablo Agustin-
dc.contributor.authorDíaz, K.P.pt_BR
dc.contributor.authorGondak, R.pt_BR
dc.contributor.authorMartins, L.L.pt_BR
dc.contributor.authorde Almeida, O.P.pt_BR
dc.contributor.authorLeón, J.E.pt_BR
dc.contributor.authorMariano, F.V.pt_BR
dc.contributor.authorAltemani, A.pt_BR
dc.contributor.authorVargas, P.A.pt_BR
dc.subjectÁcido graxo sintasespt_BR
dc.subjectNeoplasias das glândulas salivarespt_BR
dc.subject.otherlanguageFatty acid synthasept_BR
dc.subject.otherlanguageSalivary gland neoplasmspt_BR
dc.description.abstractFatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Ki‐67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki‐67. The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki‐67 may be useful diagnostic markers for CXPApt_BR
dc.relation.ispartofJournal of oral pathology and medicinept_BR
dc.relation.ispartofabbreviationJ. oral pathol. med.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2018-
dc.date.issued2018pt_BR
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume28pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage232pt_BR
dc.description.lastpage238pt_BR
dc.rightsFechadopt_BR
dc.sourcePUBMEDpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.eissn1600-0714pt_BR
dc.identifier.doi10.1111/jop.12820pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12820pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberPEC‐PG: 5881102pt_BR
dc.description.sponsordocumentnumber305967/2014-20pt_BR
dc.description.sponsordocumentnumber2012/10781-7; 2015/07304-0pt_BR
dc.date.available2020-03-23T18:57:37Z-
dc.date.accessioned2020-03-23T18:57:37Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-03-23T18:57:37Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:16:58Z : No. of bitstreams: 1 000460347600007.pdf: 2019388 bytes, checksum: 8f61ac7204e1857064efd9f8e0f3695b (MD5) Bitstreams deleted on 2021-06-23T19:41:43Z: 000460347600007.pdf,. Added 1 bitstream(s) on 2021-06-23T19:42:34Z : No. of bitstreams: 1 30597641.pdf: 2024224 bytes, checksum: 2696a0e68e6d7b61d0ecd94a9a307f92 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-23T18:57:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337207-
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordTumor cell proliferationpt_BR
dc.identifier.source30597641pt_BR
dc.creator.orcid0000-0003-2002-8003pt_BR
dc.creator.orcid0000-0003-3694-5025pt_BR
dc.creator.orcid0000-0002-9944-9734pt_BR
dc.creator.orcid0000-0003-1840-4911pt_BR
dc.type.formArtigopt_BR
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