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Type: Artigo
Title: Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma
Author: Pulido Diaz, Katya
Gondak, Rogerio
Martins, Leandro Liporoni
de Almeida, Oslei Paes
Leon, Jorge Esquiche
Mariano, Fernanda Viviane
Altemani, Albina
Vargas, Pablo Agustin
Díaz, K.P.
Gondak, R.
Martins, L.L.
de Almeida, O.P.
León, J.E.
Mariano, F.V.
Altemani, A.
Vargas, P.A.
Abstract: Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. We analyzed the expression of FASN and Ki‐67, by immunohistochemistry on 29 carcinomas ex‐pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Ki‐67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki‐67. The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki‐67 may be useful diagnostic markers for CXPA
Subject: Ácido graxo sintases
Neoplasias das glândulas salivares
Country: Reino Unido
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/jop.12820
Date Issue: 2018
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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