Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337207
Type: Artigo
Title: Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma
Author: Pulido Diaz, Katya
Gondak, Rogerio
Martins, Leandro Liporoni
de Almeida, Oslei Paes
Leon, Jorge Esquiche
Mariano, Fernanda Viviane
Altemani, Albina
Vargas, Pablo Agustin
Abstract: Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA.
Subject: Glândulas salivares
Adenoma pleomorfo
Country: Reino Unido
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/jop.12820
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12820
Date Issue: 2018
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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