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|Title:||Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma|
|Author:||Pulido Diaz, Katya|
Martins, Leandro Liporoni
de Almeida, Oslei Paes
Leon, Jorge Esquiche
Mariano, Fernanda Viviane
Vargas, Pablo Agustin
|Abstract:||Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors. Methods We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs). Results Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs, and these malignant areas also had intense nuclear immunoreactivity for Ki-67. Conclusions The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA.|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
FOP - Artigos e Outros Documentos
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