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dc.contributor.authorunicampAltemani, Albina Messias de Almeida Milani-
dc.contributor.authorunicampVargas, Pablo Agustin-
dc.titlePrognostic importance of the lymphovascular invasion in head and neck adenoid cystic carcinoma: a systematic review and meta-analysispt_BR
dc.contributor.authorMartins-Andrade, Barbara-
dc.contributor.authordos Santos Costa, Sara Ferreira-
dc.contributor.authorPereira Sant'ana, Maria Sissa-
dc.contributor.authorAltemani, Albina-
dc.contributor.authorVargas, Pablo Agustin-
dc.contributor.authorFregnani, Eduardo Rodrigues-
dc.contributor.authorAbreu, Lucas Guimaraes-
dc.contributor.authorBatista, Aline Carvalho-
dc.contributor.authorFonseca, Felipe Paiva-
dc.subjectCarcinoma adenoide cisticopt_BR
dc.subject.otherlanguageCarcinoma, adenoid cysticpt_BR
dc.description.abstractThe presence of lymphovascular invasion is considered a prognostic determinant for different human neoplasms and is frequently taken into account by surgeons and oncologists to determine patients' treatment. However, the exact frequency of this microscopic event and its prognostic impact for patients affected by adenoid cystic carcinoma (AdCC) remains unclear. Therefore, the aim of this study was to carry out a systematic review and meta-analysis to address the prevalence and the prognostic potential of lymphovascular invasion in head and neck AdCC. A literature search on PubMed, Scopus, ClinicalTrials. gov, Web of Science and ProQuest databases was undertaken in January 2019. The primary outcomes of interest were overall survival (OS) and disease-free survival (DFS). The relative frequency of lymphovascular invasion and its possible association with other clin-icopathological parameters were addressed. A total of 22 studies and 2117 patients were included in this study. The frequency of lymphovascular invasion ranged from 5.2% to 72.5%. Lymphovascular invasion was associated with an increased likelihood of lymph node metastasis (OR=2.58; 95% CI 1.61-4.12; p=0.0001) and death (OR=3.09; 95% CI 1.82-5.26; p=0.0001), solid/higher-grade AdCC were more likely to present lymphovascular invasion (OR=5.51; 95% CI 1.87-16-21; p=0.002) and patients with this microscopic finding had a significantly lower OS (HR=8.30; 95% CI 1.68-40.91; p=0.009) and DFS (HR=3.76; 95% CI 1.13-12.53; p=0.03). In conclusion, lymphovascular invasion seems to be a significant predictor of poor prognosis for head and neck AdCC patients.pt_BR
dc.relation.ispartofOral oncologypt_BR
dc.relation.ispartofabbreviationOral oncol.pt_BR
dc.publisher.countryReino Unidopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal e Nível Superiorpt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa Do Estado De Minas Geraispt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha ( on 2020-03-23T14:39:49Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-23T14:39:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordAdenoid cystic carcinomapt_BR
dc.subject.keywordSalivary gland tumorpt_BR
dc.subject.keywordLymphovascular invasionpt_BR
dc.subject.keywordVascular invasionpt_BR
dc.subject.keywordHead and neck câncerpt_BR
dc.creator.orcidSem informaçãopt_BR
dc.type.formArtigo de Revisãopt_BR
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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