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Type: Artigo
Title: Expression of mitochondrial dynamics markers during melanoma progression: comparative study of head and neck cutaneous and mucosal melanomas
Author: Soares, Ciro Dantas
de Lima Morais, Thayna Melo
Mariano, Fernanda Viviane
Altemani, Albina
Correa, Marcelo Brum
Dias dos Reis, Rodrigo Ribas
Amorim, Luciana Schultz
Soares Ferreira, Sonia Maria
de Almeida, Oslei Paes
Carlos, Roman
Jorge, Jacks
Abstract: Head and neck mucosal melanomas (MMs) are rare tumors with adverse outcomes and poorer prognoses than their more common cutaneous counterparts (cutaneous melanomas-CMs). Few studies have compared the expression of mitochondrial dynamic markers in these tumors. This study aimed to assess the correlations of mitochondrial markers with melanoma progression and their potential as predictors of lymph node involvement and distant metastasis. Methods Immunohistochemistry against anti-mitochondrial (AMT), dynamin-related protein 1 (DRP1), mitochondrial fission protein 1 (FIS1), mitofusin-1 (MFN1), and mitofusin-2 (MFN2) antibodies was performed in 112 cases of head and neck CM and MM. A Cox regression multivariate model was used to assess the correlation of AMT, FIS1, and MFN2 expressions considering the risk for nodal and distant metastasis. Results All markers studied presented higher staining in tumor cells than normal adjacent tissues. Higher mitochondrial content was observed in MM than in CM, and it was significantly associated with nodal metastasis in oral melanomas. Both FIS1 and DRP1 expressions were related to advanced Clark's levels in CM, and they were overexpressed in oral melanomas. Moreover, increased immunoexpression of MFN2 was significantly associated with a higher risk of metastasis in CM, and it was also overexpressed in sinonasal melanomas. Conclusions Our results suggest that mitochondrial fission and fusion processes can play an important role during multiple stages of tumorigenesis and the development of nodal and distant metastasis in cutaneous and mucosal melanomas.
Subject: Melanoma
Neoplasias de cabeça e pescoço
Country: Reino Unido
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/jop.12855
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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