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Type: Artigo
Title: Prognostic importance of mitochondrial markers in mucosal and cutaneous head and neck melanomas
Author: Soares, Ciro Dantas
de Lima Morais, Thayna Melo
Carlos, Roman
de Almeida, Oslei Paes
Mariano, Fernanda Viviane
Altemani, Albina
Freire de Carvalho, Maria Goretti
Correa, Marcelo Brum
Dias dos Reis, Rodrigo Ribas
Amorim, Luciana Schultz
Jorge, Jacks
Abstract: Mitochondrial dysfunction is caused by an imbalance in the fission and fusion processes, and it has been implicated in the pathogenesis of several human cancers. However, the role of mitochondria! markers in melanomas still remains poorly understood. In this study, the authors assessed the expression of 3 mitochondrial markers (antimitochondrial, fission protein 1 [FIS1], and mitofusin 2 [MFN2]) in a series of head and neck mucosal and cutaneous melanomas. Patients with cutaneous (n = 56) and mucosal (oral, n = 30, sinonasal, n = 26) melanomas of the head and neck region were enrolled in this study. Clinical and follow-up data were retrieved from medical records. The expression of 3 mitochondria] markers was assessed by the immunohistochemistry, and then digitally quantified and correlated with clinicopathological data and outcome information. In the multivariate model, high mitochondrial content was identified as an independent prognostic value for disease-free survival (DFS) in cutaneous melanomas and overall survival in oral melanomas. FIS1 expression was significantly associated with lower overall survival rates in patients with oral melanomas and strictly correlated with vascular invasion in mucosal melanomas. MFN2 was associated with high risk of distant metastasis in patients with cutaneous melanomas. In summary, the authors demonstrated that mitochondrial content, along with FIS1 and MFN2 expressions, is correlated with important clinicopathological characteristics in patients with cutaneous and mucosal head and neck melanomas. (C) 2018 Elsevier Inc. All rights reserved.
Subject: Melanoma
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.humpath.2018.11.009
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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