Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337131
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSoares, Alexandre Anderson de Sousa Munhoz-
dc.contributor.authorunicampCarvalho, Luiz Sérgio Fernandes de-
dc.contributor.authorunicampOliveira, Isabella Bonilha de-
dc.contributor.authorunicampVirginio, Vitor Wilson de Moura-
dc.contributor.authorunicampNadruz Junior, Wilson-
dc.contributor.authorunicampCoelho-Filho, Otávio Rizzi-
dc.contributor.authorunicampPetrucci Junior, Orlando-
dc.contributor.authorunicampSposito, Andrei Carvalho-
dc.typeArtigopt_BR
dc.titleAdverse interaction between HDL and the mass of myocardial infarctionpt_BR
dc.contributor.authorSoares, Alexandre A.S.-
dc.contributor.authorCarvalho, Luiz Sergio F.-
dc.contributor.authorBonilha, Isabella-
dc.contributor.authorVirginio, Vitor W.-
dc.contributor.authorNadruz Junior, Wilson-
dc.contributor.authorCoelho-Filho, Otavio Rizzi-
dc.contributor.authorSilva, Jose C. Quinaglia e-
dc.contributor.authorPetrucci Junior, Orlando-
dc.contributor.authorSposito, Andrei C.-
dc.subjectInfarto do miocárdiopt_BR
dc.subjectLipoproteinas HDLpt_BR
dc.subject.otherlanguageMyocardial infarctionpt_BR
dc.subject.otherlanguageLipoproteins, HDLpt_BR
dc.description.abstractCoronary reperfusion with HDL from healthy volunteers attenuates ischemia and reperfusion injury in animal models. In myocardial infarction (MI) patients, such an interaction is unclear. Hence, our first objective was to verify if there is interaction between HDL-C and MI mass in patients and the role of coronary reperfusion in the interaction. Furthermore, we investigated whether the effect in MI size of reperfusion with HDL obtained from healthy participants or MI patients could differ. HDL-C was measured the first day after MI and MI mass was quantified by cardiac magnetic resonance (n = 94) and peak CKMB (n = 393). In an ex vivo rat heart model, we compared MI area and dP/dt max after coronary reperfusion with HDL from MI patients or healthy volunteers. HDL-C above the median (35 mg/dL) was associated with higher peak CKMB [255 (145–415) vs. 136 (84–287) UI/L; p = 0.02], higher MI mass [17 (9–21) vs. 10 (6–14) g; p < 0.01] and lower left ventricular ejection fraction [47 (34–53) vs. 51 (43–59); p = 0.02] than their counterparts. In restricted cubic spline and multivariate linear regression, HDL-C was directly associated with peak CKMB (p < 0.01) and MI mass (p < 0.01) only in reperfused patients with time to reperfusion <4 h. Reperfusion with healthy HDL, but not from MI patients, reduced MI mass (p < 0.01) and improved dP/dt max (p = 0.02). In MI patients undergoing early coronary reperfusion, HDL-C levels at admission are directly associated with MI size. In contrast to healthy HDL, reperfusion with HDL from MI patients do not reduce MI area in an ex vivo animal model.pt_BR
dc.relation.ispartofAtherosclerosispt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-02-
dc.date.monthofcirculationFeb.pt_BR
dc.language.isoengpt_BR
dc.description.volume281pt_BR
dc.description.firstpage9pt_BR
dc.description.lastpage16pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0021-9150pt_BR
dc.identifier.eissn1879-1484pt_BR
dc.identifier.doi10.1016/j.atherosclerosis.2018.12.002pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915018315211pt_BR
dc.date.available2020-03-23T12:47:52Z-
dc.date.accessioned2020-03-23T12:47:52Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-03-23T12:47:52Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-03-23T12:47:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-02en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337131-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Cirurgiapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordMyocardial infarctionpt_BR
dc.subject.keywordHigh-density lipoproteinpt_BR
dc.subject.keywordIschemia-reperfusion injurypt_BR
dc.subject.keywordCardiac magnetic resonancept_BR
dc.subject.keywordMB creatine kinasept_BR
dc.identifier.source000459973200002pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-6465-356Xpt_BR
dc.creator.orcid0000-0002-5581-5763pt_BR
dc.creator.orcid0000-0001-9192-904Xpt_BR
dc.creator.orcid0000-0002-0003-5102pt_BR
dc.creator.orcid0000-0003-4428-5186pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-7127-2052pt_BR
dc.type.formArtigo de Periódicopt_BR
dc.description.sponsorNoteThe Brasilia Heart Study group is coordinated by Prof. Sposito and the authors of this manuscript are among those responsible for the presented data. We thank the Brasilia Heart Study participants as well as the other investigators of the study for their contributionpt_BR
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