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Type: Artigo
Title: Recent non-neurogenic overactive bladder trials
Author: Oliveira Brito, Luiz Gustavo
Teixeira dos Santos, Luis Guilherme
Abstract: Purpose of ReviewWe sought to address the most important trials regarding overactive bladder (OAB) syndrome published in the past 5years regarding pharmacological treatment and minimally invasive procedures (botulinum toxin A, percutaneous tibial nerve stimulation, and sacral neuromodulation).Recent FindingsMost of the randomized controlled trials related to OAB are studying anticholinergics and/or beta-adrenergics versus each other or to a placebo-comparator group. Studies have shown stability of using mirabegron and that combination therapy (anticholinergics plus beta-adrenoceptors) seems a good choice for patients with OAB. Percutaneous tibial nerve stimulation needs further studies with comparators to confirm its role. Regarding intra-vesical botulinic toxin or sacral neuromodulation for OAB, both options present good percentages of patient improvement, with no clinically significant difference between them to this moment.SummaryDespite a growing number of high-quality randomized trials on OAB, further studies are needed comparing different lines of treatment for this disease
Subject: Bexiga urinária hiperativa
Ensaio clínico controlado aleatório
Country: Estados Unidos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s11884-019-00501-2
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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