Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/336955
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAbdalla, Henrique Ballassini-
dc.typeArtigopt_BR
dc.titleDioclea violacea lectin ameliorates inflammation in the temporomandibular joint of rats by suppressing intercellular adhesion molecule-1 expressionpt_BR
dc.contributor.authorClemente-Napimoga, Juliana T.-
dc.contributor.authorSilva, Maria A. S. M.-
dc.contributor.authorPeres, Sylvia N. C.-
dc.contributor.authorLopes, Alexandre H. P.-
dc.contributor.authorLossio, Claudia F.-
dc.contributor.authorOliveira, Messias V.-
dc.contributor.authorOsterne, Vinicius J. S.-
dc.contributor.authorNascimento, Kyria S.-
dc.contributor.authorAbdalla, Henrique B.-
dc.contributor.authorTeixeira, Juliana M.-
dc.contributor.authorCavada, Benildo S.-
dc.contributor.authorNapimoga, Marcelo H.-
dc.subjectPeriodontitept_BR
dc.subject.otherlanguagePeriodontitispt_BR
dc.description.abstractInflammation of temporomandibular joint (TMJ) tissues are the most common cause of pain conditions associated with temporomandibular disorders (TMDs). After a tissue and/or neural damage, the inflammatory response is characterized by plasma extravasation and leukocytes infiltration in the TMJ tissues, which in turn, release inflammatory cytokines cascades responsible for inflammatory pain. Lectins are glycoproteins widely distributed in nature that may exhibit anti-inflammatory properties. This study demonstrated by molecular docking and MM/PBSA that the lectin from Dioclea violacea (DVL) interacts favorably with alpha-methyl-D-mannoside, N-acetyl-D-glucosamine, and corel-sialyl-Lewis X which are associated with leukocytes migration during an inflammatory response. Wistar rats pretreated with intravenously injection of DVL demonstrated a significant inhibition of plasma extravasation induced by carrageenan (a non-neurogenic inflammatory inductor) and mustard oil (a neurogenic inflammatory inductor) in the TMJ periarticular tissues (p <0.05; ANOVA, Tukey's test). In addition, DVL significantly reduced carrageenan-induced leukocyte migration in the TMJ periarticular tissues mediated by down-regulation of ICAM-1 expression. These results suggest a potential anti-inflammatory effect of DVL in inflammatory conditions of TMJ. (C) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reservedpt_BR
dc.relation.ispartofBiochimiept_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume158pt_BR
dc.description.firstpage34pt_BR
dc.description.lastpage42pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0300-9084pt_BR
dc.identifier.eissn1638-6183pt_BR
dc.identifier.doi10.1016/j.biochi.2018.12.007pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0300908418303523pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.date.available2020-03-19T20:56:10Z-
dc.date.accessioned2020-03-19T20:56:10Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-03-19T20:56:10Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:16:44Z : No. of bitstreams: 1 000458631000004.pdf: 1761918 bytes, checksum: 0a6cb50986590b650e8faafc7ca3e647 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-19T20:56:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/336955-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordDioclea violacea lectinpt_BR
dc.subject.keywordTemporomandibular jointpt_BR
dc.identifier.source000458631000004pt_BR
dc.creator.orcid0000-0002-7517-2830pt_BR
dc.type.formArtigo de Pesquisapt_BR
dc.description.sponsorNoteThis work was supported by - Research Productivity Fellowship to MHN, JTCN and BSC from CNPq and Post Doctoral fellowship to JMT from CAPESpt_BR
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