Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/336830
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSposito, Andrei Carvalho-
dc.contributor.authorunicampCarmo, Helison Rafael Pereira do-
dc.contributor.authorunicampOliveira, Joaquim de Paula Barreto Fonseca Antunes de-
dc.contributor.authorunicampCarvalho, Luiz Sérgio Fernandes de-
dc.typeArtigopt_BR
dc.titleHDL-Targeted therapies during myocardial infarctionpt_BR
dc.contributor.authorSposito, Andrei C.-
dc.contributor.authorCarmo, Helison R.-
dc.contributor.authorBarreto, Joaquim-
dc.contributor.authorSun, Lufan-
dc.contributor.authorCarvalho, Luiz Sergio F.-
dc.contributor.authorFeinstein, Steve B.-
dc.contributor.authorZanotti, Ilaria-
dc.contributor.authorKontush, Anatol-
dc.contributor.authorRemaley, Alan-
dc.subjectTraumatismo por reperfusãopt_BR
dc.subjectInfarto do miocárdiopt_BR
dc.subject.otherlanguageMyocardial infarctionpt_BR
dc.subject.otherlanguageReperfusion injurypt_BR
dc.description.abstractIt is now apparent that a variety of deleterious mechanisms intrinsic to myocardial infarction (MI) exists and underlies its high residual lethality. Indeed, despite effective coronary patency therapies, ischemia and reperfusion (I/R) injury accounts for about 50% of the infarcted mass. In this context, recent studies in animal models have demonstrated that coronary reperfusion with high-density lipoproteins (HDL) may reduce MI size in up to 30%. A spectrum of mechanisms mediated by either HDL-related apolipoproteins or phospholipids attenuates myocardial cell death. Hence, promising therapeutic approaches such as infusion of reconstituted HDL particles, new HDL by genomic therapy, or the infusion of apoA-I mimetic peptides have been sought as a way of ensuring protection against I/R injury. In this review, we will explore the limitations and potential therapeutic effects of HDL therapies during the acute phase of MIpt_BR
dc.relation.ispartofCardiovascular Drugs and Therapypt_BR
dc.relation.ispartofabbreviationCardiovasc Drugs Therpt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage371pt_BR
dc.description.lastpage381pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0920-3206pt_BR
dc.identifier.eissn1573-7241pt_BR
dc.identifier.doi10.1007/s10557-019-06865-1pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10557-019-06865-1pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber301465/2017-7pt_BR
dc.date.available2020-03-18T18:40:17Z-
dc.date.accessioned2020-03-18T18:40:17Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-03-18T18:40:17Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:17:51Z : No. of bitstreams: 1 000469352900012.pdf: 490947 bytes, checksum: ff687c142bbf9f7f3efae5c37a7694af (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-18T18:40:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/336830-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordHDLpt_BR
dc.subject.keywordGenomic therapypt_BR
dc.subject.keywordapoA-I mimeticspt_BR
dc.identifier.source469352900012pt_BR
dc.creator.orcid0000-0001-7127-2052pt_BR
dc.creator.orcid0000-0003-0608-8640pt_BR
dc.creator.orcid0000-0003-1914-316Xpt_BR
dc.creator.orcid0000-0001-6465-356Xpt_BR
dc.type.formArtigo de Revisãopt_BR
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