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|Title:||HDL-Targeted therapies during myocardial infarction|
|Author:||Sposito, Andrei C.|
Carmo, Helison R.
Carvalho, Luiz Sergio F.
Feinstein, Steve B.
|Abstract:||It is now apparent that a variety of deleterious mechanisms intrinsic to myocardial infarction (MI) exists and underlies its high residual lethality. Indeed, despite effective coronary patency therapies, ischemia and reperfusion (I/R) injury accounts for about 50% of the infarcted mass. In this context, recent studies in animal models have demonstrated that coronary reperfusion with high-density lipoproteins (HDL) may reduce MI size in up to 30%. A spectrum of mechanisms mediated by either HDL-related apolipoproteins or phospholipids attenuates myocardial cell death. Hence, promising therapeutic approaches such as infusion of reconstituted HDL particles, new HDL by genomic therapy, or the infusion of apoA-I mimetic peptides have been sought as a way of ensuring protection against I/R injury. In this review, we will explore the limitations and potential therapeutic effects of HDL therapies during the acute phase of MI|
|Subject:||Traumatismo por reperfusão|
Infarto do miocárdio
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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