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|Title:||Accuracy of electromagnetic models to estimate cardiomyocyte membrane polarization|
|Author:||Milan, Hugo F. M.|
Bassani, Rosana A.
Santos, Luiz E. C.
Almeida, Antonio C. G.
Bassani, Jose W. M.
|Abstract:||External electric fields (E) induce a spatially heterogeneous variation in the membrane potential (Delta V-m) of cardiomyocytes that, if sufficiently large, results in an action potential and contraction. Insights into the phenomenon of Delta V-m induction by E have been classically gained with electromagnetic models due to the lack of adequate experimental approaches. However, it is not clear yet how reliable these models are. To assess the accuracy of commonly used models, a reference 3D numerical model for cardiomyocytes (NMReal) was developed, consisting of the cell membrane shell reconstructed from rendered confocal microscopy images of freshly isolated ventricular myocytes. NMReal was used to estimate the E-induced maximum Delta V-m values (Delta V-max), which were compared with estimates from seven other electromagnetic models. Accurate Delta V-max estimates (average error < 2%) were obtained with a less complex 3D model (NM3D) based on the extruded 2D image of the cell longitudinal section. Acceptable Delta V-max estimates (average error < 5%) were obtained with the prolate spheroid analytical model (PSAM) when the angle of E incidence and the cell major axis was < 30 degrees. In this case, PSAM, a much simpler model requiring only the measurement of the longitudinal and transversal cell dimensions, can be a suitable alternative for Delta V-max calculation|
|Subject:||Análise de elementos finitos|
|Appears in Collections:||FEEC - Artigos e Outros Documentos|
CEB - Artigos e Outros Documentos
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