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Type: Artigo
Title: Protective effects of beet (beta vulgaris) leaves extract against oxidative stress in endothelial cells in vitro
Author: Salvino da Silva, Luiz Guilherme
Morelli, Ana Paula
Betim Pavan, Isadora Carolina
Tavares, Mariana Rosolen
Pestana, Nathalie Fortes
Rostagno, Mauricio Ariel
Simabuco, Fernando Moreira
Neves Bezerra, Rosangela Maria
Abstract: Beetroot is an herb used worldwide as a food product, raw material for food industry, ethanol production and source of food coloring. Beet leaves are an unconventional food with antioxidant properties, which might neutralize reactive oxygen species (ROS) induced by oxidized Low-Density Lipoprotein (LDL) present in dyslipidemias. This study aimed to elucidate the effects of beet leaves on the suppression of LDL oxidative processes. Beet leaves extract was produced, characterized, and tested for its antioxidant capacity using endothelial cells in vitro. A model of human umbilical vein endothelial cells was used in various tests, including viability assay, molecular analysis of antioxidant genes, ROS labeling, and macrophage adhesion assay. The extract improved the antioxidative protection of endothelial cells against different agents including oxidized LDL-cholesterol and H2O2. It acted on ROS directly due to its high content of natural antioxidants, but also due to the activation and improvement of cellular defenses such as Superoxide dismutase 1, Superoxide dismutase 2, and catalase. The inhibition of LDL-mediated oxidative effects on endothelial cells may turn this unconventional food a functional food with great potential for phytotherapy of atherosclerosis as an adjuvant for medicinal treatments
Subject: Estresse oxidativo
Country: Reino Unido
Editor: John Wiley & Sons
Rights: Fechado
Identifier DOI: 10.1002/ptr.6612
Date Issue: 2020
Appears in Collections:FCA - Artigos e Outros Documentos

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