Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330189
Type: Artigo
Title: Immunoexpression Of Hoxb7 And Hoxb9 In Salivary Gland Tumours
Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours
Author: Luiz Paulo
Carrinho Ayroza Rangel
Manoela Domingues
Meurer
Ricardo D.
Benevenuto de Andrade
Alan Roger
Lopes
Fernanda Viviane
Kowalski
Fonseca
Bruno Augusto
Mariano
Ana Lucia
Martins
Pablo Agustin
Keith D.
Speight
Lynne
Santos-Silva
Luise
Hunter
Marcio Ajudarte
Coletta
Felipe Paiva
Bingle
Paul M.
VargasFonseca, Felipe Paiva
Bingle, Lynne
Santos-Silva, Alan Roger
Lopes, Marcio Ajudarte
Coletta, Ricardo D.
Benevenuto de Andrade, Bruno Augusto
Mariano, Fernanda Viviane
Kowalski, Luiz Paulo
Carrinho Ayroza Rangel, Ana Lucia
Martins, Manoela Domingues
Meurer, Luise
Hunter, Keith D.
Speight, Paul M.
Vargas, Pablo Agustin
Abstract: Salivary gland carcinomas are uncommon neoplasms and the identification of new prognostic indicators could improve their management. HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms. This study investigated HOXB7 and HOXB9 expressions in salivary gland tumourigenesis, their correlation with neoplastic proliferative and angiogenic features and their importance as prognostic markers. MethodsA hundred and fifty salivary gland tumours were organized in tissue microarray and expressions of CD105, Ki67, HOXB7 and HOXB9 were determined through immunohistochemistry. Reactions were quantified and correlated with clinicopathological parameters. ResultsIn normal glands, HOXB7 was found in basal cells, whereas HOXB9 was seen in serous acinar and scattered ductal cells. Malignancies exhibited an increased vascular density, proliferative index, HOXB7 and HOXB9 expressions when compared with pleomorphic adenoma and Warthin's tumour. Significant correlation was found between HOXB7 and CD105 (P = 0.004) in adenoid cystic carcinomas, and HOXB7 higher expression significantly correlated with the presence of paresthesia (P = 0.02). No marker exhibited a significant association with survival rates (P > 0.05). ConclusionHOXB7 and HOXB9 were expressed in normal salivary gland and were present in benign and malignant tumours derived from these structures, and HOXB7 significantly correlated with neoangiogenesis in AdCC. These findings suggest that both proteins might play a role in salivary gland tumourigenesis, but they were not significant prognostic determinants in this sample.
Salivary gland carcinomas are uncommon neoplasms and the identification of new prognostic indicators could improve their management. HOXB7 and HOXB9 are members of the class I homeobox-containing genes important for normal embryogenesis and that are dysregulated in several human neoplasms. This study investigated HOXB7 and HOXB9 expressions in salivary gland tumourigenesis, their correlation with neoplastic proliferative and angiogenic features and their importance as prognostic markers. A hundred and fifty salivary gland tumours were organized in tissue microarray and expressions of CD105, Ki67, HOXB7 and HOXB9 were determined through immunohistochemistry. Reactions were quantified and correlated with clinicopathological parameters. In normal glands, HOXB7 was found in basal cells, whereas HOXB9 was seen in serous acinar and scattered ductal cells. Malignancies exhibited an increased vascular density, proliferative index, HOXB7 and HOXB9 expressions when compared with pleomorphic adenoma and Warthin's tumour. Significant correlation was found between HOXB7 and CD105 (P = 0.004) in adenoid cystic carcinomas, and HOXB7 higher expression significantly correlated with the presence of paresthesia (P = 0.02). No marker exhibited a significant association with survival rates (P > 0.05). HOXB7 and HOXB9 were expressed in normal salivary gland and were present in benign and malignant tumours derived from these structures, and HOXB7 significantly correlated with neoangiogenesis in AdCC. These findings suggest that both proteins might play a role in salivary gland tumourigenesis, but they were not significant prognostic determinants in this sample
Subject: Adenoid Cystic Carcinoma
Hoxb7
Hoxb9
Mucoepidermoid Carcinoma
Salivary Gland Tumours
Neoplasias das glândulas salivares
Editor: Wiley-Blackwell
Hoboken
Citation: Journal Of Oral Pathology & Medicine. Wiley-blackwell, v. 45, p. 672 - 681, 2016.
Rights: aberto
Identifier DOI: 10.1111/jop.12438
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12438
Date Issue: 2016
Appears in Collections:FOP - Artigos e Outros Documentos

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