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Type: Artigo
Title: In Vivo And In Vitro Effects Of Curcumin On Head And Neck Carcinoma: A Systematic Review
Author: Borges
Gabriel Alvares; Rego
Daniela Fortunato; Assad
Daniele Xavier; Coletta
Ricardo D.; Canto
Graziela De Luca; Silva Guerra
Eliete Neves
Abstract: Head and neck squamous cell carcinoma (HNSCC) contributes globally to a great number of deaths and morbidity, in spite of new therapeutic strategies. There is a great need of new drugs that are significantly effective and less deleterious to the patients' general health. In this sense, phytotherapy is a tendency, with results pointing to its use as a chemo-preventive and adjuvant therapy. Therefore, the objective of this systematic review was to investigate the effects of curcumin on proliferation and survival of HNSCC. MATERIALS AND METHODS: The search was conducted on six databases: Cochrane, LILACS, EMBASE, MEDLINE, PubMed, and Web of Science. In vitro and in vivo studies that evaluated the effects of curcumin on cell viability, tumor growth, cell cycle and/or cell death pattern in HNSCC cell lines or animal models were selected. RESULTS: Of the 525 initially gathered studies, 30 met the inclusion criteria. These studies demonstrated that curcumin induces cytotoxicity, apoptosis ( via intrinsic pathway), and cell cycle arrest in G(2)/M phase in HSNCC cell lines. It also reduces tumor measurements in animal models. These events were mostly studied through MTT assay, flow cytometry, and cell cycle-and apoptosisrelated proteins expression. CONCLUSION: This systematic review demonstrated that curcumin is effective on HNSCC cell proliferation and survival, reinforcing the currently available evidence that curcumin could be an adjuvant drug in HNSCC treatment.
Subject: Curcumin
Head And Neck Neoplasms
Systematic Review
Editor: Wiley-Blackwell
Citation: Journal Of Oral Pathology & Medicine. Wiley-blackwell, v. 46, p. 3 - 20, 2017.
Rights: fechado
Identifier DOI: 10.1111/jop.12455
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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