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Type: Artigo
Title: Mismatch Repair System Proteins In Oral Benign And Malignant Lesions
Author: do Amaral-Silva
Gleyson Kleber; Martins
Manoela Domingues; Rebelo Pontes
Helder Antonio; Fregnani
Eduardo Rodrigues; Lopes
Marcio Ajudarte; Fonseca
Felipe Paiva; Vargas
Pablo Agustin
Abstract: Different environmental agents may cause DNA mutations by disrupting its double-strand structure; however, even normal DNA polymerase function may synthesize mismatch nucleotide bases, occasionally demonstrating failure in its proofreading activity. To overcome this issue, mismatch repair (MMR) system, a group of proteins specialized in finding mispairing bases and small loops of insertion or deletion, works to avoid the occurrence of mutations that could ultimately lead to innumerous human diseases. In the last decades, the role of MMR proteins in oral carcinogenesis and in the development of other oral cavity neoplasms has grown, but their importance in the pathogenesis and their prognostic potential for patients affected by oral malignancies, especially oral squamous cell carcinoma (OSCC), remain unclear. Therefore, in this manuscript we aimed to review and critically discuss the currently available data on MMR proteins expression in oral potentially malignant lesions, in OSCC, and in other oral neoplasms to better understand their relevance in these lesions.
Subject: Leukoplakia
Mismatch Repair System
Oral Cancer
Editor: Wiley-Blackwell
Citation: Journal Of Oral Pathology & Medicine. Wiley-blackwell, v. 46, p. 241 - 245, 2017.
Rights: fechado
Identifier DOI: 10.1111/jop.12484
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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