Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330180
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailcscereda@gmail.compt_BR
dc.contributor.authorunicampCereda, Cintia Maria Saiapt_BR
dc.contributor.authorunicampGuilherme Damasio, Viviane Aparecidapt_BR
dc.contributor.authorunicampAlkschbirs, Melissa Ingerpt_BR
dc.contributor.authorunicampFranz-Montan, Michellept_BR
dc.contributor.authorunicampPaula, Eneida dept_BR
dc.typeArtigopt_BR
dc.titleLiposomal Butamben Gel Formulations: Toxicity Assays And Topical Anesthesia In An Animal Modelen
dc.titleLiposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal modelpt_BR
dc.contributor.authorSaia Cereda, Cintia Mariapt_BR
dc.contributor.authorGuilherme, Viviane Aparecidapt_BR
dc.contributor.authorAlkschbirs, Melissa Ingerpt_BR
dc.contributor.authorde Brito Junior, Rui Barbosapt_BR
dc.contributor.authorTofoli, Giovana Radomillept_BR
dc.contributor.authorFranz-Montan, Michellept_BR
dc.contributor.authorde Araujo, Daniele Ribeiropt_BR
dc.contributor.authorde Paula, Eneidapt_BR
unicamp.authorde Paula, Eneida] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazilpt_BR
unicamp.author[Alkschbirs, Melissa Inger] Univ Estadual Campinas, Inst Chem, Dept Phys Chem, Campinas, SP, Brazilpt_BR
unicamp.author[Franz-Montan, Michelle] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, SP, Brazilpt_BR
unicamp.author.external[Saia Cereda, Cintia Mariapt_BR
unicamp.author.externalGuilherme, Viviane Aparecidapt_BR
unicamp.author.external[de Brito Junior, Rui Barbosapt_BR
unicamp.author.externalTofoli, Giovana Radomille] Sao Leopoldo Mand Dent Res Inst, Dept Mol Biol, Campinas, SP, Brazilpt_BR
unicamp.author.external[de Araujo, Daniele Ribeiro] Fed Univ ABC, Human & Nat Sci Ctr, Santo Andre, SP, Brazilpt_BR
dc.subjectButambenen
dc.subjectLiposomesen
dc.subjectLocal Anestheticsen
dc.subjectTopical Anesthesiaen
dc.subjectAnestésicos locaispt_BR
dc.subjectLipossomaspt_BR
dc.subject.otherlanguageLocal anestheticspt_BR
dc.subject.otherlanguageLiposomespt_BR
dc.description.abstractThe aim of this study was to evaluate the in vitro cytotoxicity and the in vivo analgesic effect and local toxicity of the local anesthetic butamben (BTB) encapsulated in conventional or elastic liposomes incorporated in gel formulations. The results showed that both gel formulations of liposomal BTB reduced the cytotoxicity (p<0.001; one-way ANOVA/Tukey's test) and increased the topical analgesic effect (p<0.05; one-way ANOVA/Tukey's test) of butamben, compared to plain BTB gel. The gel formulations presented good rheological properties, and stability assays detected no differences in physicochemical stability up to 30 d after preparation. Moreover, histological assessment revealed no morphological changes in rat skin after application of any of the gel formulations tested.en
dc.description.abstractThe aim of this study was to evaluate the in vitro cytotoxicity and the in vivo analgesic effect and local toxicity of the local anesthetic butamben (BTB) encapsulated in conventional or elastic liposomes incorporated in gel formulations. The results showed that both gel formulations of liposomal BTB reduced the cytotoxicity (p<0.001; one-way ANOVA/Tukey's test) and increased the topical analgesic effect (p<0.05; one-way ANOVA/Tukey's test) of butamben, compared to plain BTB gel. The gel formulations presented good rheological properties, and stability assays detected no differences in physicochemical stability up to 30 d after preparation. Moreover, histological assessment revealed no morphological changes in rat skin after application of any of the gel formulations testedpt
dc.relation.ispartofJournal of liposome researchpt_BR
dc.relation.ispartofabbreviationJ liposome respt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherInforma Healthcarept_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationMar.pt_BR
dc.identifier.citationJournal Of Liposome Research . Taylor & Francis Ltd, v. 27, p. 74 - 82, 2017.pt_BR
dc.language.isoengpt_BR
dc.description.volume27pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage74pt_BR
dc.description.lastpage82pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.sourceWOSpt_br
dc.identifier.issn0898-2104pt_BR
dc.identifier.eissn1532-2394pt_BR
dc.identifier.wosidWOS:000393927800008pt_BR
dc.identifier.doi10.3109/08982104.2016.1160924pt_BR
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.3109/08982104.2016.1160924pt_BR
dc.description.sponsorshipCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORpt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber2611/09-0pt_BR
dc.description.sponsordocumentnumber2006/00121-9pt_BR
dc.date.available2017-11-13T13:58:03Z-
dc.date.accessioned2017-11-13T13:58:03Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:58:03Z (GMT). No. of bitstreams: 1 000393927800008.pdf: 952231 bytes, checksum: 32a0e4106ec17b7231cd699b30d4a6fb (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330180-
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentInformação não localizadapt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordTopical anesthesiapt_BR
dc.subject.keywordButambenpt_BR
dc.identifier.source393927800008-
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcidInformação não localizadapt_BR
dc.creator.orcid0000-0003-0760-1389pt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.type.formArtigo-
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