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Type: Artigo
Title: Liposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal model
Author: Saia Cereda, Cintia Maria
Guilherme, Viviane Aparecida
Alkschbirs, Melissa Inger
de Brito Junior, Rui Barbosa
Tofoli, Giovana Radomille
Franz-Montan, Michelle
de Araujo, Daniele Ribeiro
de Paula, Eneida
Abstract: The aim of this study was to evaluate the in vitro cytotoxicity and the in vivo analgesic effect and local toxicity of the local anesthetic butamben (BTB) encapsulated in conventional or elastic liposomes incorporated in gel formulations. The results showed that both gel formulations of liposomal BTB reduced the cytotoxicity (p<0.001; one-way ANOVA/Tukey's test) and increased the topical analgesic effect (p<0.05; one-way ANOVA/Tukey's test) of butamben, compared to plain BTB gel. The gel formulations presented good rheological properties, and stability assays detected no differences in physicochemical stability up to 30 d after preparation. Moreover, histological assessment revealed no morphological changes in rat skin after application of any of the gel formulations tested
Subject: Anestésicos locais
Country: Estados Unidos
Editor: Taylor & Francis
Citation: Journal Of Liposome Research . Taylor & Francis Ltd, v. 27, p. 74 - 82, 2017.
Rights: fechado
Identifier DOI: 10.3109/08982104.2016.1160924
Date Issue: 2017
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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