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Type: Congresso
Title: Incorporation And Release Kinetics Of Alpha-bisabolol From Pcl And Chitosan/guar Gum Membranes
Author: Bombaldi de Souza
F. C.; Bombaldi de Souza
R. F.; Moraes
A. M.
Abstract: Alpha-bisabolol, an anti-inflammatory and antioxidant compound extracted from candeia trees (Eremanthus erythropappus), was incorporated into hydrophobic polycaprolactone (PCL) and hydrophilic chitosan/guar gum (Ch-G) membranes aiming at the production of bioactive wound dressings. The incorporation efficiency achieved a maximum of ca. 18% (1 gram of alpha-bisabolol per gram of membrane) for Ch-G membranes. For PCL membranes, all of the active compound added was retained (0.2 gram of alpha-bisabolol per gram of membrane). Alpha-bisabolol release in phosphate-buffered saline was relatively slow in both cases, reaching around 6% and 24% after 120 hours respectively for PCL and Ch-G membranes presenting equivalent initial alpha-bisabolol/membrane mass ratios. Both formulations were capable of releasing alpha-bisabolol in the typically recommended topical dose range (from 1 to 10 grams of alpha-bisabolol per gram of vehicle). The extended release periods observed are advantageous, allowing less frequent dressing changes and contributing to turn the treatment more comfortable for the patient.
Subject: Wound Dressing
Guar Gum
Alpha - Bisabolol
Editor: Brazilian Soc Chemical Eng
São Paulo
Citation: Brasilian Journal Of Chemical Engineering. Brazilian Soc Chemical Eng , v. 33, p. 453 - 467, 2016.
Rights: aberto
Identifier DOI: 10.1590/0104-6632.20160333s20150083
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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