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Type: Artigo
Title: Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration In A Pig Model
Author: Cardoso
Marcio Vivan; Chaudhari
Amol; Yoshihara
Kumiko; Mesquita
Marcelo Ferraz; Yoshida
Yasuhiro; Van Meerbeek
Bart; Vandamme
Katleen; Duyck
Abstract: To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration. Materials and Methods: Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un)coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with alpha = .05 was used to statistically compare BF and BIC of the coated and uncoated implants. Results: Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P < .05) and for both healing periods (P < .05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P < .05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P < .05). Conclusion: These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.
Subject: Bone
Organic Coating
Titanium Implant
Editor: Quintessence Publishing Co Inc
Hanover Park
Citation: International Journal Of Oral & Maxillofacial Implants. Quintessence Publishing Co Inc, v. 32, p. 282 - 290, 2017.
Rights: fechado
Identifier DOI: 10.11607/jomi.5074
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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