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Type: Artigo
Title: Mechanisms In Endocrinology: Hypothalamic Inflammation And Nutrition
Author: Araujo
Eliana P.; Moraes
Juliana C.; Cintra
Dennys E.; Velloso
Licio A.
Abstract: Selected subpopulations of hypothalamic neurons play important roles in the regulation of whole body energy homeostasis. Studies have shown that the saturated fats present in large amounts in western diets can activate an inflammatory response in the hypothalamus, affecting the capacity of such neurons to respond appropriately to satiety and adipostatic signals. In the first part of this review, we will explore the mechanisms behind saturated fatty acid-induced hypothalamic dysfunction. Next, we will present and discuss recent studies that have identified the mechanisms that mediate some of the anti-inflammatory actions of unsaturated fatty acids in the hypothalamus and the potential for exploring these mechanisms to prevent or treat obesity.
Editor: Bioscientifica LTD
Citation: European Journal Of Endocrinology. Bioscientifica Ltd, v. 175, p. R97 - R105, 2016.
Rights: fechado
Identifier DOI: 10.1530/EJE-15-1207
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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