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Type: Artigo
Title: Acetaminophen-induced Hepatotoxicity: Preventive Effect Of Trans Anethole
Author: da Rocha
Bruno Ambrosio; Versuti Ritter
Alessandra M.; Ames
Franciele Queiroz; Goncalves
Odinei Hess; Leimann
Fernanda Vitoria; Bracht
Livia; Marcal Natali
Maria Raquel; Nakamura Cuman
Roberto Kenji; Bersani-Amado
Ciomar Ap.
Abstract: The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-parabenzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause irreversible lesions. Associated with this process, an intense inflammatory process is also evidenced, characterized by the increased cell influx and production/release of inflammatory mediators. Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE(2)), cytokines (TNF, IL-1) and nitrico oxide (NO). The aim of this study is to investigate the effect of trans anethole on some inflammatory parameters that are involved in hepatotoxicity induced by high doses of acetaminophen. Our results demonstrate that treatment with AN at doses 125 and 250 mg/kg once a day for seven days prevented the changes caused by the APAP overdose, showing less intensity in the histological changes (necrosis, size of hepatocyte area and inflammatory infiltration), and corroborating the findings of serum activities of transaminases and phosphatases and the activity of the enzyme myeloperoxidase. In addition, the treatment prevented the up-regulation of proinflammatory mediators such as NO, TNF, IL-1 alpha, MIP-1 alpha and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10). Thus, our results demonstrate a possible protective effect of trans anethole on the hepatotoxicity induced by APAP. (C) 2016 Elsevier Masson SAS. All rights reserved.
Subject: Trans Anethole
Editor: Elsevier France-Editions Scientifiques Medicales Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.biopha.2016.12.014
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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