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Type: Artigo
Title: Amphiphilic Nucleating Agents To Enhance Calcium Phosphate Growth On Polymeric Surfaces
Author: da Silva
Laura C. E.; Mas
Bruna A.; Duek
Eliana A. R.; Landers
Richard; Bertran
Celso A.; Goncalves
Maria C.
Abstract: Poly(epsilon-caprolactone) (PCL) is an aliphatic polyester widely explored in the preparation of guided bone regeneration (GBR) membranes because of its interesting mechanical properties and biodegradability. However, PCL high hydrophobicity often impairs cell adhesion and proliferation as well as calcium phosphate growth, all of which are crucial to achieving suitable bone tissue integration. In this work, aimed at achieving less-hydrophobic surfaces, amphiphilic molecules were added at low concentrations. to the polymeric dope solutions that generated the GBR membranes, During membrane formation, these molecules migrate to the solution/air interface in such a way that, upon liquid solid phase transition, the negatively charged heads are exposed while the apolar tails are anchored to the polymer bulk. As a consequence, these molecules became nucleating agents for subsequent calcium phosphate growth using an alternating soaking process. Herein, PCL porous membranes containing different amphiphilic molecules, such as stearic acid and bis(2,ethylhexyl) phosphate, were investigated. This. new, simple, and atoxic method to.superficially treat polymeric membranes could be extended to a wide range of polymers and applications.
Editor: Amer Chemical Soc
Rights: fechado
Identifier DOI: 10.1021/acs.langmuir.6b04562
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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