Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330082
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremaillpinato@marilia.unesp.brpt_BR
dc.typeArtigopt_BR
dc.titleMelatonin And Circadian Rhythms In Autism: Case Reporten
dc.contributor.authorZuculopt_BR
dc.contributor.authorGabriela Melloni; Goncalvespt_BR
dc.contributor.authorBruno S. B.; Brittespt_BR
dc.contributor.authorClay; Menna-Barretopt_BR
dc.contributor.authorLuiz; Pinatopt_BR
dc.contributor.authorLucianapt_BR
unicamp.author[Brittes, Clay] Univ Estadual Campinas, Lab Dificuldades & Disturbios Aprendizagem & Tran, Campinas, Brazilpt_BR
unicamp.author.external[Zuculo, Gabriela Mellonipt_BR
unicamp.author.externalPinato, Luciana] Univ Estadual Paulista, Av Hygino Muzzi Filho 737, BR-17525000 Marilia, SP, Brazilpt_BR
unicamp.author.external[Goncalves, Bruno S. B.pt_BR
unicamp.author.externalMenna-Barreto, Luiz] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, Brazilpt_BR
dc.subjectNeurodevelopmental Disorderen
dc.subjectSleepen
dc.subjectActigraphyen
dc.subjectBehavioren
dc.description.abstractAmong the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm. This ASD subject showed before melatonin administration an activity/rest rhythm lower than 24 hours. The results show that melatonin increased approximately 4.7 times the regularity of circadian activity rhythm and resting staying on average between 00:00 and 06:00 and showed positive effects in improving the quality of sleep and behavior. So, the actigraphy showed an ASD subject with a non-24-hour activity/rest rhythm which changed this rhythm to a 24-hour rhythm after melatonin administration. This result reinforces the prospect of therapy with melatonin for synchronization (increased regularity) of endogenous rhythms and improve sleep quality and hence behavior and indicates the actigraphy as a choice tool to characterize several parameters of the activity/rest rhythm of ASD individuals.en
dc.relation.ispartofChronobiology Internationalpt_BR
dc.publisherTaylor & Francis Incpt_BR
dc.publisherPhiladelphiapt_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationmaiopt_BR
dc.identifier.citationChronobiology International . Taylor & Francis Inc, v. 34, p. 527 - 530, 2017.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume34pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage527pt_BR
dc.description.lastpage530pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0742-0528pt_BR
dc.identifier.eissn1525-6073pt_BR
dc.identifier.wosidWOS:000399901900011pt_BR
dc.identifier.doi10.1080/07420528.2017.1308375pt_BR
dc.identifier.urlhttp://www.tandfonline.com/doi/abs/10.1080/07420528.2017.1308375?tab=permissions&scroll=toppt_BR
dc.description.sponsorshipCNPq [480208/2013-1, 166068/2015-2]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:57:42Z-
dc.date.accessioned2017-11-13T13:57:42Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:57:42Z (GMT). No. of bitstreams: 1 000399901900011.pdf: 783613 bytes, checksum: c582d0523d8a74662e6c94d15db082ff (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330082-
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