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Type: Artigo
Title: Dietary Fiber And The Short-chain Fatty Acid Acetate Promote Resolution Of Neutrophilic Inflammation In A Model Of Gout In Mice
Author: Vieira
Angelica T.; Galvao
Izabela; Macia
Laurence M.; Sernaglia
Erica M.; Vinolo
Marco Aurelio R.; Garcia
Cristiana C.; Tavares
Luciana P.; Amaral
Flavio A.; Sousa
Lirlandia P.; Martins
Flaviano S.; Mackay
Charles R.; Teixeira
Mauro M.
Abstract: Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue damage. We investigated the effects of a high-fiber diet and acetate, a short-chain fatty acid (SCFA) resulting from the metabolism of fiber by gut microbiota, on the inflammatory response in an experimental model of gout in mice. Injection of MSU crystals into the knee joint of mice induced neutrophil influx and inflammatory hypernociception. The onset of inflammatory response induced by MSU crystals was not altered in animals given a high-fiber diet, but the high-fiber diet induced faster resolution of the inflammatory response. Similar results were obtained in animals given the SCFA acetate. Acetate was effective, even when given after injection of MSU crystals at the peak of the inflammatory response and induced caspase-dependent apoptosis of neutrophils that accounted for the resolution of inflammation. Resolution of neutrophilic inflammation was associated with decreased NF-kappa B activity and enhanced production of anti-inflammatory mediators, including IL-10, TGF-beta, and annexin A1. Acetate treatment or intake of a high-fiber diet enhanced efferocytosis, an effect also observed in vitro with neutrophils treated with acetate. In conclusion, a high-fiber diet or one of its metabolic products, acetate, controls the inflammatory response to MSU crystals by favoring the resolution of the inflammatory response. Our studies suggest that what we eat plays a determinant role in our capacity to fine tune the inflammatory response. Introduction
Subject: Microbiota
Editor: Federation Amer Soc Exp Biol
Citation: Journal Of Leukocyte Biology. Federation Amer Soc Exp Biol, v. 101, p. 275, 2017.
Rights: fechado
Identifier DOI: 10.1189/jlb.3A1015-453RRR
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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