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Type: Artigo
Title: Synthesis, Antifungal Activity Of Caffeic Acid Derivative Esters, And Their Synergism With Fluconazole And Nystatin Against Candida Spp.
Author: Orlandi Sardi
Janaina de Cassia; Gullo
Fernanda Patricia; Freires
Irian Almeida; Pitangui
Nayla de Souza; Segalla
Maicon Petronio; Marisa Fusco-Almeida
Ana; Rosalen
Pedro Luiz; Regasini
Luis Octavio; Soares Mendes-Giannini
Maria Jose
Abstract: We tested the antifungal potential of caffeic acid and 8 of its derivative esters against Candidaalbicans ATCC 90028 and 9 clinical isolatesand carried out a synergism assay with fluconazole and nystatin. Propyl caffeate (C3) showed the best antifungal activity against the tested strains. When in combination, C3 markedly reduced the MIC of fluconazole and nystatin with synergistic effect up to 64-fold. Finally, C3 showed a high IC50 value and selective indexagainst oral keratinocytes, demonstrating low toxicity against this cell type and selectivity for yeast cells. Further research should confirm its antifungal potential for development of combined therapy to treat C. albicans infections. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Synergism
Candida Albicans
Caffeic Acid
Editor: Elsevier Science INC
New York
Rights: fechado
Identifier DOI: 10.1016/j.diagmicrobio.2016.08.002
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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