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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLandim, Ricardo Cesar Giorgettipt_BR
dc.contributor.authorunicampLi, Li Minpt_BR
dc.contributor.authorunicampCovolan, Roberto José Mariapt_BR
dc.contributor.authorunicampCastellano, Gabrielapt_BR
dc.typeArtigopt_BR
dc.titleInvestigation Of Naa And Naag Dynamics Underlying Visual Stimulation Using Mega-press In A Functional Mrs Experimenten
dc.titleInvestigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experimentpt_BR
dc.contributor.authorLandim, R. C. G.pt_BR
dc.contributor.authorEdden, R. A. E.pt_BR
dc.contributor.authorFoerster, B.pt_BR
dc.contributor.authorLi, L. M.pt_BR
dc.contributor.authorCovolan, R. J. M.pt_BR
dc.contributor.authorCastellano, G.pt_BR
dc.subjectProton Magnetic Resonance Spectroscopyen
dc.subjectN-acetyl-aspartateen
dc.subjectN-acetyl-aspartyl-glutamateen
dc.subjectVisual Stimulationen
dc.subjectFunctional Experimentsen
dc.subjectMega-pressen
dc.subjectEspectroscopia de ressonância magnética protônica, N-acetil-aspartato, N-acetil-aspartil-glutamatopt_BR
dc.subject.otherlanguageProton magnetic resonance spectroscopy, N-acetylaspartate, N-acetyl-aspartyl-glutamatept_BR
dc.description.abstractN-acetyl-aspartate (NAA) is responsible for the majority of the most prominent peak in H-1-MR spectra, and has been used as diagnostic marker for several pathologies. However, similar to 10% of this peak can be attributed to N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide whose release may be triggered by intense neuronal activation. Separate measurement of NAA and NAAG using MRS is difficult due to large superposition of their spectra. Specifically, in functional MRS (fMRS) experiments, most work has evaluated the sum NM + NAAG, which does not appear to change during experiments. The aim of this work was to design and perform an fMRS experiment using visual stimulation and a spectral editing sequence, MEGA-PRESS, to further evaluate the individual dynamics of NM and NAAG during brain activation. The functional paradigm used consisted of three blocks, starting with a rest (baseline) block of 320 s, followed by a stimulus block (640 s) and a rest block (640 s). Twenty healthy subjects participated in this study. On average, subjects followed a pattern of NAA decrease and NAAG increase during stimulation, with a tendency to return to basal levels at the end of the paradigm, with a peak NM decrease of-(21 +/- 19)% and a peak NAAG increase of (64 62)% (Wilcoxon test p < 0.05). These results may relate to: 1) the only known NAAG synthesis pathway is from NM and glutamate; 2) a relationship between NAAG and the BOLD response. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.abstractN-acetyl-aspartate (NAA) is responsible for the majority of the most prominent peak in H-1-MR spectra, and has been used as diagnostic marker for several pathologies. However, similar to 10% of this peak can be attributed to N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide whose release may be triggered by intense neuronal activation. Separate measurement of NAA and NAAG using MRS is difficult due to large superposition of their spectra. Specifically, in functional MRS (fMRS) experiments, most work has evaluated the sum NM + NAAG, which does not appear to change during experiments. The aim of this work was to design and perform an fMRS experiment using visual stimulation and a spectral editing sequence, MEGA-PRESS, to further evaluate the individual dynamics of NM and NAAG during brain activation. The functional paradigm used consisted of three blocks, starting with a rest (baseline) block of 320 s, followed by a stimulus block (640 s) and a rest block (640 s). Twenty healthy subjects participated in this study. On average, subjects followed a pattern of NAA decrease and NAAG increase during stimulation, with a tendency to return to basal levels at the end of the paradigm, with a peak NM decrease of-(21 +/- 19)% and a peak NAAG increase of (64 62)% (Wilcoxon test p < 0.05). These results may relate to: 1) the only known NAAG synthesis pathway is from NM and glutamate, 2) a relationship between NAAG and the BOLD response.pt_BR
dc.relation.ispartofMagnetic resonance imagingpt_BR
dc.relation.ispartofabbreviationMagn. reson. imagingpt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationApr.pt_BR
dc.identifier.citationMagnetic Resonance Imaging. Elsevier Science Inc, v. 34, p. 239 - 245, 2016.pt_BR
dc.language.isoengpt_BR
dc.description.volume34pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage239pt_BR
dc.description.lastpage245pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0730-725Xpt_BR
dc.identifier.eissn1873-5894pt_BR
dc.identifier.doi10.1016/j.mri.2015.10.038pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0730725X15002921pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber2005/56578-4, 2009/10046-2, 2011/01106-1, 2013/07559-3pt_BR
dc.date.available2017-11-13T13:57:38Z-
dc.date.accessioned2017-11-13T13:57:38Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:57:38Z (GMT). No. of bitstreams: 1 000371649900001.pdf: 1179909 bytes, checksum: 5ec5ecc18e55d2675af9dbab67b126ed (MD5) Previous issue date: 2016 Bitstreams deleted on 2020-09-02T13:43:14Z: 000371649900001.pdf,. Added 1 bitstream(s) on 2020-09-02T13:47:43Z : No. of bitstreams: 1 000371649900001.pdf: 1248847 bytes, checksum: ccafef290afb0e6a12883d6e31c53af7 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/330059-
dc.contributor.departmentDepartamento de Raios Cósmicos e Cronologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Raios Cósmicos e Cronologiapt_BR
dc.contributor.departmentDepartamento de Raios Cósmicos e Cronologiapt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.subject.keywordVisual stimulation, Functional experiments, Mega-presspt_BR
dc.identifier.source000371649900001pt_BR
dc.creator.orcid0000-0001-6801-3519pt_BR
dc.creator.orcid0000-0001-6272-5339pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0002-5927-487Xpt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteWe thank Elvis Lira da Silva (UNICAMP, Brazil) for programming the paradigms in the E-prime software. This work was supported by São Paulo Research Foundation (FAPESP – Brazil), grants 2005/56578-4, 2009/10046-2, 2011/01106-1, 2013/07559-3. This project applied tools developed under NIH grants P41 EB015909 and R01 EB016089.pt_BR
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