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Type: Artigo
Title: High-fat Diet During Pregnancy And Lactation Impairs The Cholinergic Anti-inflammatory Pathway In The Liver And White Adipose Tissue Of Mouse Offspring
Author: Payolla
Tanyara Baliani; Lemes
Simone Ferreira; de Fante
Thais; Reginato
Andressa; da Silva
Cristiano Mendes; Micheletti
Thayana de Oliveira; Rodrigues
Hosana Gomes; Torsoni
Adriana Souza; Milanski
Marciane; Torsoni
Marcio Alberto
Abstract: Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-alpha was elevated in the HFD-O mice. STAT3 and NF-kappa B activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-alpha and IL-1 beta expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP. (C) 2015 Published by Elsevier Ireland Ltd.
Subject: Alpha 7nachr
Cholinergic Anti-inflammatory Pathway
Maternal Imprinting
Obese Mice
High-fat Diet
Editor: Elsevier Science BV
Rights: fechado
Identifier DOI: 10.1016/j.mce.2015.12.004
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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