Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329801
Type: Artigo
Title: Bonding Performance Of Experimental Bioactive/biomimetic Self-etch Adhesives Doped With Calcium-phosphate Fillers And Biomimetic Analogs Of Phosphoproteins
Author: Abuna
Gabriel; Feitosa
Victor P.; Correr
Americo Bortolazzo; Cama
Giuseppe; Giannini
Marcelo; Sinhoreti
Mario A.; Pashley
David H.; Sauro
Salvatore
Abstract: This study examined the bonding performance and dentin remineralization potential of an experimental adhesive containing calcium-phosphate (Ca/P) micro-fillers, and self-etching primers doped with phosphoprotein biomimetic analogs (polyacrylic acid-(PAA) and/or sodium trimetaphosphate-(TMP)). Methods: Experimental self-etching primers doped with biomimetic analogs (PAA and/or TMP), and an adhesive containing Ca2+, PO4-3-releasing micro-fillers (Ca/P) were formulated. Sound human dentin specimens were bonded and cut into sticks after aging (24 h or 6 months) under simulated pulpal pressure (20 cm H2O), and tested for microtensile bond strength (mu TBS). Results were analyzed using two-way ANOVA and Tukey's test (p < 0.05). Interfacial silver nanoleakage was assessed using SEM. Remineralization of EDTA-demineralized dentin was assessed through FTIR and TEM ultrastructural analysis. Results: Application of the Ca/P-doped adhesive with or without dentin pre-treatments with the primer containing both biomimetic analogs (PAA and TMP) promoted stable mTBS over 6 months. Conversely, mTBS of the control primer and filler-free adhesive significantly decreased after 6 months. Nanoleakage decreased within the resin-dentin interfaces created using the Ca/P-doped adhesives. EDTA-demineralized dentin specimens treated the Ca/P-doped adhesive and the primer containing PAA and TMP showed phosphate uptake (FTIR analysis), as well as deposition of needle-like crystallites at intrafibrillar level (TEM analysis). Significance: The use of Ca/P-doped self-etching adhesives applied in combination with analogs of phosphoproteins provides durable resin-dentin bonds. This approach may represent a suitable bonding strategy for remineralization of intrafibrillar dentin collagen within the resin-dentin interface. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Adhesive
Biomimetic Remineralization
Collagen
Dentin
Self-etching
Editor: Elsevier SCI LTD
Oxford
Rights: fechado
Identifier DOI: 10.1016/j.jdent.2016.07.016
Address: http://www.sciencedirect.com/science/article/pii/S0300571216301439?via%3Dihub
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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