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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR; j-s-becker@gmx.netpt_BR
dc.titleLaser Ablation Icp-ms: Application In Biomedical Researchen
dc.contributor.authorAlessandra; Beckerpt_BR
dc.contributor.authorJ. Susanne; Beckerpt_BR
dc.contributor.authorJ. Sabinept_BR[Sussulini, Alessandra] Univ Estadual Campinas, Inst Chem, Dept Analyt Chem, POB 6154, BR-13083970 Campinas, SP, Brazilpt_BR[Becker, J. Susanne] Maschweg 86, D-33790 Halle, Germanypt_BR[Becker, J. Sabine] Forschungszentrum Julich, Zent Inst Engn Elekt & Analyt Analyt ZEA 3, D-52425 Julich, Germanypt_BR
dc.subjectImaging Mass Spectrometryen
dc.subjectLaser Ablation Inductively Coupled Plasma Mass Spectrometryen
dc.subjectMolecular Mass Spectrometryen
dc.subjectBrain Diseasesen
dc.description.abstractIn the last decade, the development of diverse bioanalytical methodologies based on mass spectrometry imaging has increased, as has their application in biomedical questions. The distribution analysis of elements (metals, semimetals, and nonmetals) in biological samples is a point of interest in life sciences, especially within the context of metallomics, which is the scientific field that encompasses the global analysis of the entirety of elemental species inside a cell or tissue. Laser ablation inductively coupled plasma mass spectrometry (LAICP-MS) has been efficiently employed to generate qualitative and quantitative maps of elemental distribution in thin tissue sections of a variety of biological samples, for example, brain, cartilage, spinal cord, etc. The combination of elemental with molecular mass spectrometry allows obtaining information about the elements bound to proteins, when they are previously separated by gel electrophoresis (metalloproteomics), and also adding a new dimension to molecular mass spectrometry imaging by the correlation of molecular and elemental distribution maps in definite regions in a biological tissue. In the present review, recent biomedical applications in LA-ICP-MS imaging as a stand-alone technique and in combination with molecular mass spectrometry imaging techniques are discussed. Applications of LA-ICP-MS in the study of neurodegenerative diseases, distribution of contrast agents and metallodrugs, and metalloproteomics will be focused in this review. (C) 2015 Wiley Periodicals, Inc.en
dc.relation.ispartofMass Spectrometry Reviewspt_BR
dc.identifier.citationMass Spectrometry Reviews . Wiley-blackwell, v. 36, p. 47 - 57, 2017.pt_BR
dc.description.sponsorshipAlexander von Humboldt Foundation (Bonn, Germany)pt_BR
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG) [BE 2649/5-1]pt_BR
dc.description.provenanceMade available in DSpace on 2017-11-13T13:55:57Z (GMT). No. of bitstreams: 1 000394658200004.pdf: 3410802 bytes, checksum: 48ac09ca4b6f837949c2d82a2d5d9a15 (MD5) Previous issue date: 2017en
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