Please use this identifier to cite or link to this item:
Type: Artigo
Title: Laser Ablation Icp-ms: Application In Biomedical Research
Author: Sussulini
Alessandra; Becker
J. Susanne; Becker
J. Sabine
Abstract: In the last decade, the development of diverse bioanalytical methodologies based on mass spectrometry imaging has increased, as has their application in biomedical questions. The distribution analysis of elements (metals, semimetals, and nonmetals) in biological samples is a point of interest in life sciences, especially within the context of metallomics, which is the scientific field that encompasses the global analysis of the entirety of elemental species inside a cell or tissue. Laser ablation inductively coupled plasma mass spectrometry (LAICP-MS) has been efficiently employed to generate qualitative and quantitative maps of elemental distribution in thin tissue sections of a variety of biological samples, for example, brain, cartilage, spinal cord, etc. The combination of elemental with molecular mass spectrometry allows obtaining information about the elements bound to proteins, when they are previously separated by gel electrophoresis (metalloproteomics), and also adding a new dimension to molecular mass spectrometry imaging by the correlation of molecular and elemental distribution maps in definite regions in a biological tissue. In the present review, recent biomedical applications in LA-ICP-MS imaging as a stand-alone technique and in combination with molecular mass spectrometry imaging techniques are discussed. Applications of LA-ICP-MS in the study of neurodegenerative diseases, distribution of contrast agents and metallodrugs, and metalloproteomics will be focused in this review. (C) 2015 Wiley Periodicals, Inc.
Subject: Imaging Mass Spectrometry
Laser Ablation Inductively Coupled Plasma Mass Spectrometry
Molecular Mass Spectrometry
Brain Diseases
Editor: Wiley-Blackwell
Citation: Mass Spectrometry Reviews . Wiley-blackwell, v. 36, p. 47 - 57, 2017.
Rights: fechado
Identifier DOI: 10.1002/mas.21481
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000394658200004.pdf3.33 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.