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Type: Artigo
Title: Pancreatitis Subtypes Survey In 852 Childhood-onset Systemic Lupus Erythematosus Patients
Author: Marques
Victor L. S.; Gormezano
Natali W. S.; Bonfa
Eloisa; Aikawa
Nadia E.; Terreri
Maria T.; Pereira
Rosa M.; Magalhaes
Claudia S.; Guariento
Andressa; Appenzeller
Simone; Ferriani
Virginia P.; Barbosa
Cassia M.; Ramos
Valeria C.; Lotufo
Simone; Silva
Clovis A.
Abstract: Pancreatitis is a rare and a life-threatening systemic lupus erythematosus (SLE) manifestation in childhood-onset SLE (cSLE). The objective of this study was to systematically classify pancreatitis in cSLE according to the International Study Group of Pediatric Pancreatitis and determine the overall prevalence, clinical features, laboratory, and first episode outcomes.Methods:A multicenter cohort study in 10 pediatric rheumatology centers, including 852 patients with cSLE.Results:Pancreatitis was diagnosed in 22 of 852 (2.6%) patients with cSLE. It was classified as acute pancreatitis in 20 (91%), acute recurrent pancreatitis in 2 (9%), and none of them had chronic pancreatitis. None of them had gallstones, traumatic pancreatitis, or reported alcohol/tobacco use. The comparison of patients with pancreatitis (first episode) and without this complication revealed a shorter disease duration (1 [0-10] vs 4 [0-23] years, P<0.0001) and higher median of Systemic Lupus Erythematosus Disease Activity Index 2000 (21 [0-41] vs 2 [0-45], P<0.0001). The frequencies of fever (P<0.0001), weight loss (P<0.0001), serositis (P<0.0001), nephritis (P<0.0001), arterial hypertension (P<0.0001), acute renal failure (P<0.0001), macrophage activation syndrome (P<0.0001), and death (P=0.001) were also higher in patients with pancreatitis. The frequencies of intravenous methylprednisolone use (P<0.0001) and the median of prednisone dose (55 [15-60] vs 11 [1-90] mg/day, P<0.0001) were significantly higher in patients with pancreatitis. Of note, the 2 patients with acute recurrent pancreatitis had 2 episodes, with pain-free interval of 1 and 4 years.Conclusions:This was the first study characterizing pancreatitis using the International Study Group of Pediatric Pancreatitis standardized definitions in patients with cSLE showing that the predominant form is acute pancreatitis seen in association with glucocorticoid treatment and active severe disease.
Subject: Childhood-onset Systemic Lupus Erythematosus
Systemic Lupus Erythematosus Disease Activity Index
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/MPG.0000000000000990
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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