Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329739
Type: Artigo
Title: Low-level Laser Therapy Stimulates Tissue Repair And Reduces The Extracellular Matrix Degradation In Rats With Induced Arthritis In The Temporomandibular Joint
Author: Lemos
George Azevedo; Rissi
Renato; de Souza Pires
Ivan Luiz; de Oliveira
Leticia Prado; de Aro
Andrea Aparecida; Pimentel
Edson Rosa; Palomari
Evanisi Teresa
Abstract: The objective of this study was to characterize morphological and biochemistry action of low-level laser therapy (LLLT) on induced arthritis in the temporomandibular joint (TMJ) of rats. Twenty-four male Wistar rats were randomly divided into groups with 12 animals each: (AG) group with arthritis induced in the left TMJ and (LG) group with arthritis induced in the left TMJ and treated with LLLT (830 nm, 30 mW, 3 J/cm(2)). Right TMJs in the AG group were used as noninjected control group (CG). Arthritis was induced by intra-articular injection of 50 mu l Complete Freund's Adjuvant (CFA) and LLLT began 1 week after arthritis induction. Histopathological analysis was performed using sections stained with hematoxylin-eosin, Toluidine Blue, and picrosirius. Biochemical analysis was determined by the total concentration of sulfated glycosaminoglycans (GAGs) and evaluation of matrix metalloproteinases (MMP-2 and MMP-9). Statistical analysis was performed using paired and unpaired t tests, with p < 0.05. Compared to AG, LG had minor histopathological changes in the TMJ, smaller thickness of the articular disc in the anterior (p < 0.0001), middle (p < 0.0001) and posterior regions (p < 0.0001), high birefringence of collagen fibers in the anterior (p < 0.0001), middle (p < 0.0001) and posterior regions (p < 0.0001) on the articular disc, and statistically lower activity of MMP-2 latent (p < 0.0001), MMP-2 active (P = 0.02), MMP-9 latent (p < 0.0001), and MMP-9 active (p < 0.0001). These results suggest that LLLT can increase the remodeling and enhancing tissue repair in TMJ with induced arthritis.
Subject: Temporomandibular Joint Disorders
Arthritis
Inflammation
Low-level Laser Therapy
Editor: Springer London LTD
London
Rights: fechado
Identifier DOI: 10.1007/s10103-016-1946-3
Address: https://link.springer.com/article/10.1007/s10103-016-1946-3
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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