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Type: Artigo
Title: The Antioxidant Effects Of Green Tea Reduces Blood Pressure And Sympathoexcitation In An Experimental Model Of Hypertension
Author: Garcia
Michelle L.; Pontes
Roberto B.; Nishi
Erika E.; Ibuki
Flavia K.; Oliveira
Vanessa; Sawaya
Alexandra C. H.; Carvalho
Patricia O.; Nogueira
Fernando N.; Franco
Maria do Carmo; Campos
Ruy R.; Oyama
Lila M.; Bergamaschi
Cassia T.
Abstract: Oxidative stress is a key mediator in the maintenance of sympathoexcitation and hypertension in human and experimental models. Green tea is widely known to be potent antioxidant. Objective: We aimed to evaluate the effects of green tea in a model of hypertension. Methods: Hypertension was induced by the nitric oxide synthase inhibitor [N-nitro-L-arginine-methyl-ester (L-NAME); 20mg/kg per day, orally, for 2 weeks] in male Wistar rats. After the first week of L-NAME treatment, animals received green tea ad libitum for 1 week. At the end of the treatment period, blood pressure, heart rate, baroreflex sensitivity, renal sympathetic nerve activity, and vascular and systemic oxidative stress were assessed. Results: L-NAME-treated animals exhibited an increase in blood pressure (165 +/- 2 mmHg) compared with control rats (103 +/- 1mmHg) and green tea treatment reduced hypertension (119 +/- 1 mmHg). Hypertensive animals showed a higher renal sympathetic nerve activity (161 +/- 12 spikes/s) than the control group (97 +/- 2 spikes/s), and green tea also decreased this parameter in the hypertensive treated group (125 5 spikes/s). Arterial baroreceptor function and vascular and systemic oxidative stress were improved in hypertensive rats after green tea treatment. Conclusions: Taken together, short-term green tea treatment improved cardiovascular function in a hypertension model characterized by sympathoexcitation, which may be because of its antioxidant properties.
Subject: Green Tea
Oxidative Stress
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/HJH.0000000000001149
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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