Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329638
Type: Artigo
Title: A Pharmacological Perspective On The Use Of Brazilian Red Propolis And Its Isolated Compounds Against Human Diseases
Author: Freires
Irlan Almeida; de Alencar
Severino Matias; Rosalen
Pedro Luiz
Abstract: Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and economic value. The nutraceutical and pharmacological benefits of propolis have been extensively explored in several fields of medicine as an important resource for prevention and treatment of oral and systemic diseases. A relatively new type of propolis, named red propolis (in Brazil, Brazilian Red Propolis - BRP), has been arousing attention for the promising pharmacological properties of some of its isolated compounds (vestitol, neovestitol, quercetin, medicarpin, formononetin, etc). Due to a distinct chemical composition, BRP and its isolated compounds (mainly isoflavones) affect a wide range of biological targets and could have an impact against numerous diseases as an antimicrobial, anti-inflammatory and immunomodulatory, antioxidant and antiproliferative agent. In this review, we comprehensively address the main aspects related to BRP bioprospection, chemistry and therapeutic potential. Further information is provided on mechanisms of action discovered thus far as well as clinical use in humans and regulatory aspects. As of now, BRP and its isolated molecules remain a fascinating topic for further research and application in biomedical areas and dentistry. (C) 2016 Elsevier Masson SAS. All rights reserved.
Subject: Red Propolis
Isoflavones
Antimicrobial
Anti-inflammatory
Antioxidant
Antiproliferative
Editor: Elsevier France-Editions Scientifiques Medicales Elsevier
Paris
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2016.01.033
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0223523416300332?via%3Dihub
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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