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Type: Artigo
Title: Synthesis Of Novel 2-aryl-3-(2-morpholinoethyl)-1,3-thiazinan-4-ones Via Ultrasound Irradiation
Author: Gouvea
Daniela P.; Berwaldt
Gabriele A.; Neuenfeldt
Patricia D.; Nunes
Ricardo J.; Almeida
Wanda P.; Cunico
Abstract: This study describes the synthesis of fourteen thiazinanones from a multicomponent reaction of 2-morpholinoehtylamine (as primary amine), arenealdehydes (as carbonyl compound) and the mercaptopropionic acid using both conventional (thermal heating) and ultrasound methodologies. Through thermal heating methodology, the thiazinanones were obtained in 49 to 97% yields for 16 hours and through sonochemistry methodology, the reaction time was reduced for 25 minutes with yields 41 to 88%. The full identification and characterization of unpublished heterocycles were achieved by proton (H-1) and carbon 13 (C-13) nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and infrared. Some of them were also characterized by elemental analysis.
Subject: Thiazinanone
Multicomponent Reaction
Editor: Soc Brasileira Quimica
São Paulo
Rights: aberto
Identifier DOI: 10.5935/0103-5053.20160009
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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